腹腔内伴EWSR1/FUS-CREM重排恶性上皮样肿瘤1例  

Intra-abdominal EWSR1/FUS-CREM rearranged malignant epithelioid neoplasms:report of a case

作　　者：吴佳慧 许淑霞 徐曼 沈萍 陈洁枫 金晓婷 Chik Hong Kuick Kenneth Tou En Chang 殷敏智[1] Wu Jiahui;Xu Shuxia;Xu Man;Shen Ping;Chen Jiefeng;Jin Xiaoting;Kuick Chik Hong;Kenneth Tou En Chang;Yin Minzhi(Department of Pathology,Shanghai Children′s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine,Shanghai 200127,China;Department of Pathology,Fujian Children′s Hospital(Fujian Branch of Shanghai Children′s Medical Center),Fuzhou 350011,China;Department of Pathology,Children′s Hospital Affiliated to Chongqing Medical University,Chongqing 400000,China;Department of Pathology and Laboratory Medicine,KK Women′s and Children′s Hospital,Singapore 229899,Singapore)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心病理科,上海200127 [2]福建省儿童医院(上海儿童医学中心福建医院)病理科,福州350011 [3]重庆医科大学附属儿童医院病理科,重庆400000 [4]Department of Pathology and Laboratory Medicine,KK Women′s and Children′s Hospital,Singapore 229899,Singapore

出　　处：《中华病理学杂志》2024年第3期299-302,共4页Chinese Journal of Pathology

摘　　要：腹腔内伴EWSR1/FUS-CREM重排恶性上皮样肿瘤是新近发现、分化不明的恶性肿瘤,形态学及免疫表型显示上皮分化,具有恶性潜能及转移倾向。本文报道1例多次复发伴肺转移的病例。镜下肿瘤界限尚清,有纤维性假包膜,肿瘤周边及细胞巢间隔见较多炎性细胞浸润,肿瘤细胞呈上皮样、多边形,胞质丰富,呈嗜酸性,核呈圆形或卵圆形,可见小核仁。肿瘤细胞上皮细胞膜抗原弥漫强阳性,广谱细胞角蛋白局灶强阳性,波形蛋白、WT1、突触素、Calretinin等阴性。分子检测示EWSR1-ATF1融合。

关 键 词：腹腔内 转移倾向 假包膜 免疫表型 波形蛋白 肺转移 纤维性 恶性肿瘤 

分 类 号：R735[医药卫生—肿瘤]