肠道类器官:评价肉与肉制品中食源性致病菌感染的新工具  

Intestinal Organoids:A New Tool for Infection Assessment of Foodborne Pathogens from Meat and Meat Products

作　　者：王旭 刘奂辰 王丽明 王惠鑫 王义翔 王怡 张岩 WANG Xu;LIU Huanchen;WANG Liming;WANG Huixin;WANG Yixiang;WANG Yi;ZHANG Yan(Hebei Food Safety Key Laboratory,Key Laboratory of Special Food Supervision Technology for State Market Regulation,Hebei Engineering Research Center for Special Food Safety and Health,Hebei Food Inspection and Research Institute,Shijiazhuang 050227,China;National Center of Standards Evaluation,State Administration for Market Regulation,Beijing 100026,China;Key Laboratory for Industrial Biocatalysis,Ministry of Education,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China)

机构地区：[1]河北省食品检验研究院,河北省食品安全重点实验室,国家市场监管重点实验室(特殊食品监管技术),特殊食品安全与健康河北省工程研究中心,河北石家庄050227 [2]国家市场监督管理总局国家标准技术审评中心,北京100026 [3]清华大学化学工程系生物化工研究所,工业生物催化教育部重点实验室,北京100084

出　　处：《肉类研究》2024年第1期75-81,共7页Meat Research

基　　金：国家市场监督管理总局技术保障专项(2023YJ22,2023YJ37);河北省市场监督管理局科研计划项目(2024ZD02);特殊食品监管技术重点实验室建设项目(2021JG46)。

摘　　要：肉及肉制品是人类膳食结构中必不可少的组成部分,因其含有丰富的营养成分,易被食源性致病菌污染,进而对人体健康造成极大的伤害。因此,预防和控制肉及肉制品中食源性致病菌感染对食品安全具有重要意义。为深入了解整个感染过程中食源性致病菌和上皮细胞之间的关系,建立研究食源性致病菌的有效肠道评价模型是控制食源性危害的前提。基于此,本文对肉及肉制品中常见的食源性致病菌感染情况进行总结,并对目前食源性致病菌感染的体内外模型进行讨论。其中,肠道类器官作为评价食源性致病菌感染机制的新模型,在致病机制、细胞和组织趋向性方面具有较大应用潜力。因此,本文重点阐述肠道类器官模型在食源性致病菌感染机制方面的研究现状,并在现有肠道类器官模型特点和问题的基础上对肠道类器官的发展方向提出展望。Meat and meat products are an essential part of the human diet.Being nutritious,they are easily contaminated by foodborne pathogens,which causes serious damage to human health.Therefore,the prevention and control of foodborne pathogen contamination in meat and meat products is of great importance for food safety.In order to deeply understand the relationship between foodborne pathogens and epithelial cells in the whole infection process,it is a prerequisite to establish an effective intestinal evaluation model.Accordingly,this paper summarizes the infection status of common foodborne pathogens in meat and meat products,and discusses the in vivo and in vitro models currently used to assess the infection of foodborne pathogens.Among them,intestinal organoids,a new model to evaluate the infection mechanism of foodborne pathogens,have great potential in the research of the pathogenic mechanism,cell and tissue tropism.Therefore,this paper focuses on the current status of the application of intestinal organoid models in research on the infection mechanism of foodborne pathogens,and discusses the characteristics and problems of the current intestinal organoid models as well as future development directions.

关 键 词：肉及肉制品 食源性致病菌 评价模型 肠道类器官 

分 类 号：TS201.3[轻工技术与工程—食品科学]