Study on the mechanism of action of Feng-Liao-Chang-Wei-Kang combined with 5-fluorouracil in the treatment of colitis-associated colon cancer  

作　　者：WANG Qian-ru ZHONG Li-fan HUANG Ling 

机构地区：[1]Hainan Province Key Laboratory for Drug Preclinical Study of Pharmacology and Toxicology Research,Haikou 570100,China [2]Key Laboratory of Hainan Trauma and Disaster Rescue,Haikou 570100,China [3]Hainan Research Center for Drug Safety Evaluation,Hainan Medical College,Haikou 57119,China [4]School of Pharmaceutical Sciences Hainan Medical University,Haikou 57119,China

出　　处：《Journal of Hainan Medical University》2023年第18期1-6,共6页海南医学院学报（英文版）

基　　金：National Natural Science of China(No.81760674);Hainan Graduate Innovative Research Project(No.Hys2020-371)。

摘　　要：Objective:To investigate the therapeutic effects and mechanisms of Feng-Liao-Chang-Wei-Kang combined with 5-fluorouracil administration in mice with colitis-associated colon cancer.Methods:To establish a colitis-associated colon cancer mouse model and observe the behavior and activity of mice after Feng-Liao-Chang-Wei-Kang and 5-fluorouracil administration;HE staining to observe the pathological changes of mouse colonic tissue;Western blot was used to detect the expression of mouse colon tissue in IL-6/STAT3 pathway-related proteins.Results:The survival rate of mice in the co-administered group was significantly increased,and the intestinal wall thickening and interstitial inflammation of mice were significantly reduced.Western blot results showed that the expression levels of P-STAT3 and IL-6 were significantly increased in the colonic tissue of mice after modeling,and the combined administration inhibited the expression of Cyclin D1,CDK4 and Bcl-2 protein in the IL-6/STAT3 pathway and upregulated the expression of Bax(P<0.05).Conclusion:Feng-Liao-Chang-Wei-Kang combined with 5-fluorouracil inhibits IL-6/STAT3 pathway to exert inhibition of colitis-associated colon cancer inhibition of colitis-associated colon cancer.

关 键 词：Colitis-associated colon cancer Feng-Liao-Chang-Wei-Kang 5-FLUOROURACIL IL-6/STAT3 

分 类 号：R735.35[医药卫生—肿瘤]