CfDNA-based liquid biopsy of cerebrospinal fluid in medulloblastoma  

作　　者：FU Bing-biao ZHAO Ze-yu AN Si-long CHEN Hua-shuai ZHAO Jian-nong 

机构地区：[1]Hainan Medical University,Haikou,570311,China

出　　处：《Journal of Hainan Medical University》2023年第18期70-74,共5页海南医学院学报（英文版）

基　　金：Key Social Development Project in Hainan Province(No.ZDYF2019173)。

摘　　要：Medulloblastoma(MB)is the most common childhood embryonal malignant tumour in the central nervous system.The diagnosis,prognosis and therapeutic targets of MB depend on the molecular characteristics of the tumor,and it is a great challenge to obtain the tissue samples from the patients with brain tumor.Genomic changes found in cell-free DNA(cfDNA)of cerebrospinal fluid(CSF)can predict genomic changes present in tumor tissue,fluid biopsy of CSF can detect the genomic profile of tumor-associated cfDNA and evaluate cfDNA as a marker of measurable residual disease(MRD)in a relatively noninvasive manner,which provides the evidence of"individualized precision therapy"for MB patients.In this paper,we reviewed the recent studies in medulloblastoma based on cfDNA Liquid Biopsy of CSF.

关 键 词：MEDULLOBLASTOMA Liquid biopsy of cerebrospinal fluid cfDNA 

分 类 号：R739.41[医药卫生—肿瘤]