Learning human liver biology in humanized mice  

作　　者：Brandon M.Lehrich P.Monga 

机构地区：[1]Division of Experimental Pathology,Department of Pathology and Pittsburgh Liver Institute,University of Pittsburgh School of Medicine,Pittsburgh,PA,USA [2]Division of Gastroenterology,Hepatology and Nutrition,Department of Medicine,University of Pittsburgh School of Medicine,Pittsburgh,PA,USA

出　　处：《Cell Research》2024年第1期9-10,共2页细胞研究（英文版）

摘　　要：A new study describes development of a chimeric mouse liver repopulated with nearly all human hepatic cell types albeit to varying extents.This model yielded novel information on unique human hepatocyte metabolic function which is regulated by local microenvironmental signals,specifically sinusoidal endothelial cell-secreted WNT2.

关 键 词：LIVER HEPATIC HEPATOCYTE 

分 类 号：R575[医药卫生—消化系统]