原发性肾滑膜肉瘤伴下腔静脉癌栓1例报告  

Renal synovial sarcoma with inferior vena cava tumor thrombosis:a case report

作　　者：张俊隆[1] 陈羽[1] 梁月有[1] 曹明欣[1] Zhang Junlong;Chen Yu;Liang Yueyou;Cao Mingxin(Department of Urology,The First affiliated Hospital,Sun Yat-sen University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院泌尿外科,广州510080

出　　处：《中华泌尿外科杂志》2024年第2期144-145,共2页Chinese Journal of Urology

摘　　要：本文报道1例原发性肾滑膜肉瘤合并下腔静脉癌栓病例。患者男,32岁,因反复右侧腹痛就诊。术前CT检查考虑右肾癌合并下腔静脉癌栓,行根治性右肾切除及下腔静脉癌栓取出术,术后病理诊断为肾滑膜肉瘤。患者行基因分子病理检查提示应用环磷酰胺类药物预后较好,免疫负相关基因阴性。术后参考基因检测结果行一线异环磷酰胺和表柔比星化疗。术后1年患者出现肺转移,更换派安普利单抗、安罗替尼、吉西他滨、多西他赛综合治疗,患者完全缓解。基因检测在此类恶性肿瘤辅助治疗上可能有一定的参考价值。A case of primary renal synovial sarcoma with inferior vena cava tumor thrombus was reported.The male patient was 32 years old,presenting recurrent right abdominal pain.Preoperative CT scan revealed right renal cell carcinoma combined with inferior vena cava tumor thrombus.He underwent radical nephrectomy of the right kidney and removal of inferior vena cava tumor thrombus.After operation,the pathology suggested renal synovial sarcoma.The patient's genetic molecular pathology suggested a better prognosis treating by cyclophosphamide-related therapy and negative immune related genes.The patient underwent first-line chemotherapy with ifosfamide and epirubicin.One year later,the patient developed lung metastasis and was treated with a combination of pembrolizumab,arotinib,gemcitabine,and docetaxel.The patient achieved complete remission.It is suggested that genetic test may have a value in the adjuvant treatment for this malignant tumor.

关 键 词：肾肿瘤 滑膜肉瘤 下腔静脉瘤栓 基因检测 

分 类 号：R737.11[医药卫生—肿瘤]