原发性胆汁性胆管炎遗传易感性的研究现状  

Current status of research on the genetic susceptibility of primary biliary cholangitis

作　　者：赵春梅[1] 马狄 邰文琳[1] ZHAO Chunmei;MA Di;TAI Wenlin(Department of Clinical Laboratory,The Second Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第二附属医院检验科,昆明650032

出　　处：《临床肝胆病杂志》2024年第3期606-610,共5页Journal of Clinical Hepatology

基　　金：国家自然科学基金(82060385);昆明医科大学2023年研究生创新基金(2023S321)。

摘　　要：原发性胆汁性胆管炎(PBC)是一种以胆管上皮细胞变性坏死为主,好发于中老年女性,具有强烈的遗传倾向性的肝脏自身免疫性疾病。随着全基因组关联分析(GWAS)的不断发展,PBC的遗传易感性备受关注。本文阐述了与PBC密切相关的遗传易感基因的研究进展,以期为PBC治疗提供有效靶点。Primary biliary cholangitis(PBC)is a liver autoimmune disease with a strong genetic tendency characterized by the degeneration and necrosis of bile duct epithelial cells,and it is often observed in middle-aged and elderly women.With the continuous development of genome-wide association studies,the genetic susceptibility of PBC has attracted more and more attention.This article elaborates on the research advances in the genetic susceptibility genes closely associated with PBC,in order to provide effective targets for the treatment of PBC.

关 键 词：原发性胆汁性胆管炎 疾病遗传易感性 HLA抗原 

分 类 号：R575.7[医药卫生—消化系统]