Strain-dependent alpha-synuclein spreading in Parkinson's disease and multiple system atrophy  

作　　者：Shuyu Zhang Paul Lingor 

机构地区：[1]Department of Neurology,School of Medicine,University Hospital rechts der Isar,Technical University of Munich,Munich,Germany [2]Department of Neurology,University Medical Center Göttingen,Göttingen,Germany [3]Center for Biostructural Imaging of Neurodegeneration,University Medical Center Göttingen,Göttingen,Germany

出　　处：《Neural Regeneration Research》2024年第12期2581-2582,共2页中国神经再生研究（英文版）

基　　金：supported by Deutsche Forschungsgemeinschaft;EXC 2145 SyNergy;Grant No.390857198 (to PL)。

摘　　要：Parkinson's disease(PD) and atypical Parkinsonian syndromes,such as multiple system atrophy(MSA) and Dementia with Lewy bodies,are neurodegenerative movement disorders characterized by the accumulation of alphasynuclein(a-syn) aggregates.These a-syn aggregates propagate throughout the brain in a prion-like manner,where pathological a-syn recruits endogenous a-syn to form insoluble aggregates.Oligomeric forms representing intermediates on the way to insoluble aggregates result in the most pronounced neurotoxic effects.

关 键 词：ATROPHY ENDOGENOUS ATYPICAL 

分 类 号：R742.5[医药卫生—神经病学与精神病学]