Immunogenic molecules associated with gut bacterial cell walls:chemical structures,immune-modulating functions,and mechanisms  

作　　者：Ruopeng Yin Tao Wang Huanqin Dai Junjie Han Jingzu Sun Ningning Liu Wang Dong Jin Zhong Hongwei Liu 

机构地区：[1]State Key Laboratory of Mycology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [2]Savaid Medical School,University of Chinese Academy of Sciences,Beijing 100049,China [3]CAS Key Laboratory of Pathogenic Microbiology and Immunology,Institute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China [4]State Key Laboratory of Microbial Resources,Institute of Microbiology,Chinese Academy of Sciences,100101 Beijing,China

出　　处：《Protein & Cell》2023年第10期776-785,共10页蛋白质与细胞（英文版）

基　　金：The work was financially supported by a grant from National Key R&D Program of China(2022YFA1304200).

摘　　要：Interactions between gut microbiome and host immune system are fundamental to maintaining the intestinal mucosal barrier and homeostasis.At the host-gut microbiome interface,cell wall-derived molecules from gut commensal bacteria have been reported to play a pivotal role in training and remodeling host immune responses.In this article,we review gut bacterial cell wall-derived molecules with characterized chemical structures,including peptidoglycan and lipid-related molecules that impact host health and disease processes via regulating innate and adaptive immunity.Also,we aim to discuss the structures,immune responses,and underlying mechanisms of these immunogenic molecules.Based on current advances,we propose cell wall-derived components as important sources of medicinal agents for the treatment of infection and immune diseases.

关 键 词：gut commensal bacteria PEPTIDOGLYCAN lipid-related molecules immune responses 

分 类 号：R574[医药卫生—消化系统]