PEPTIDOGLYCAN

作品数：19被引量：59H指数：5
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相关作者：罗丽刘娟娟李亚东孙婉金媛媛更多>>
相关机构：河北联合大学中国医学科学院北京协和医学院湖南农业大学中国科学技术大学更多>>
相关期刊：《Cellular & Molecular Immunology》《Open Journal of Medical Microbiology》《World Journal of Gastroenterology》《Chinese Medicine》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金上海市自然科学基金更多>>
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Combatting Pathogenic Bacteria with Synthetic Immunotherapeutics from Chitosan:Antibody Recruiting at Engineered Bacterial Surface with Peptidoglycan Analogs
《CCS Chemistry》2024年第6期1448-1457,共10页Yuan Xu Shihao Song Hongwei Duan Yinyue Deng Xue-Wei Liu 
the Ministry of Education(grant nos.MOET2EP30120-0007 and MOE2018-T2-2-128);the National Research Foundation(grant no.NRF-CRP22-2019-0002);Agency for Science,Technology and Research(A*STAR);Singapore(grant no.A20E5c0087);the National Natural Science Foundation of China(grant no.32300033);the Scientific Research Foundation of Hainan University(grant nos.KYQD(ZR)-22173 and KYQD(ZR)-23006).
The emergence of microbial drug resistance,coupled with the paucity of new antibiotics poses an impending threat to public health.In this work,we drew inspiration from synthetic peptidoglycan oligomers and successfull...
关键词：CHITOSAN bacterial infection endogenous antibodies bacterial surface engineering peptidoglycan analogs 
Immunogenic molecules associated with gut bacterial cell walls:chemical structures,immune-modulating functions,and mechanisms被引量：2
《Protein & Cell》2023年第10期776-785,共10页Ruopeng Yin Tao Wang Huanqin Dai Junjie Han Jingzu Sun Ningning Liu Wang Dong Jin Zhong Hongwei Liu 
The work was financially supported by a grant from National Key R&D Program of China(2022YFA1304200).
Interactions between gut microbiome and host immune system are fundamental to maintaining the intestinal mucosal barrier and homeostasis.At the host-gut microbiome interface,cell wall-derived molecules from gut commen...
关键词：gut commensal bacteria PEPTIDOGLYCAN lipid-related molecules immune responses 
Peptidoglycan inhibits beigeing of adipose tissue被引量：1
《Acta Pharmaceutica Sinica B》2022年第2期990-993,共4页Hong Chen Lijun Sun Lu Feng Michael Mulholland Weizhen Zhang Yue Yin 
supported by grants from the National Natural Science Foundation of China(81730020,81930015,and 82070592);National Institutes of Health Grant R01D K112755,1R01DK129360 and 1R01DK110273(USA)。
To the Editor:Obesity, an epidemic metabolic disease characterized by excessive fat accumulation, causes a significant economic burden on families and the society. The discovery of beige adipocytes has provided us wit...
关键词：Beige adipocytes Brown adipocytes OBESITY Metabolic inflammation 
Peptidoglycan-inspired autonomous ultrafast self-healing bio-friendly elastomers for bio-integrated electronics被引量：5
《National Science Review》2021年第5期125-134,共10页Luzhi Zhang Jiahui Liang Chenyu Jiang Zenghe Liu Lijie Sun Shuo Chen Huixia Xuan Dong Lei Qingbao Guan Xiaofeng Ye Zhengwei You 
supported by the National Natural Science Foundation of China(21991123,21574019,21304015 and81671832);the Natural Science Foundation of Shanghai(20ZR1402500 and 18ZR1401900);the Shanghai Belt and Road Joint Laboratory of Advanced Fiber and Low-dimension Materials(Donghua University)(18520750400);the Fundamental Research Funds for the Central Universities;DHU Distinguished Young Professor Program(LZA2019001);Graduate Student Innovation Fund of Donghua University(CUSF-DH-D-2020037);the Shanghai Municipal Key Clinical Specialty Construction Project(shslczdzk01702);the Science and Technology Commission of Shanghai(17DZ2260100)。
Elastomers are essential for stretchable electronics,which have become more and more important in bio-integrated devices.To ensure high compliance with the application environment,elastomers are expected to resist,and...
关键词：biomimetic elastomers ultrafast self-healing bio-integrated electronics stretchable conductor 
Protective Effect of Bacillus subtilis Peptidoglycan (PG) on β-conglycinin-induced Intestinal Epithelial Cells Damage of Juvenile Carp (Cyprinus carpio)被引量：3
《Animal Husbandry and Feed Science》2019年第2期56-61,共6页Zhang Tiantian Yin Haicheng Huang Wei 
Supported by Science and Technology Research Project of Henan Province(172102110205)
[Objective] The paper was to investigate the protective effects of different concentrations of Bacillus subtilis peptidoglycan(PG) on β-conglycinin-induced inflammatory injury in intestinal epithelial cells of juveni...
关键词：CARP (Cyprinus carpio) Bacillus subtilis PG Β-CONGLYCININ Intestinal epithelial cell (IECs) Antioxidant Inflammatory factor 
Clinical Isolates of Staphylococcus aureus Show Variation in β-Lactamase Production and Are More Susceptible to Antibiotics Conjugated with β-Lactamase Inhibitors
《Open Journal of Medical Microbiology》2016年第4期143-149,共7页Uzal Umar Umar Ahmed Faruk Damoroem M. Tanko Mohammed B. Yerima 
β-Lactam antibiotics are a cornerstone in the treatment of bacterial infections on account of its high therapeutic index and selective toxicity—they act by inhibiting the biosynthesis of peptidoglycan, a key compone...
关键词：Β-LACTAMASE PEPTIDOGLYCAN Transpeptidation HAEMOLYSIS Resistance ANTIBIOTICS 
An Herbal Formula (GPC) Suppresses the Releases of Pro-Inflammatory Effectors in Lipopolysaccharide/Peptidoglycan-Activated RAW264.7 Macrophages and Reduces the Extent of Chemical-Induced Acute/Chronic Inflammation in Rodents被引量：1
《Chinese Medicine》2016年第4期153-165,共14页Pou Kuan Leong Hoi Yan Leung Wing Man Chan Jihang Chen Huawei Zhu Jialing Ning Yiting Yang Chung Wah Ma Kam Ming Ko 
Pharyngitis (an inflammation in the pharynx) is a commonly occurring symptom of upper respiratory tract infection in patients suffering from common cold. The high prevalence of upper respiratory tract infection necess...
关键词：PHARYNGITIS Glycyrrhiza Radix Platycodonis Radix Citri Reticulatae Pericarpium Phyllanthi Fructus Taraxaci Herba 
Structural insights into the regulatory mechanism of the Pseudomonas aeruginosa YfiBNR system被引量：2
《Protein & Cell》2016年第6期403-416,共14页Min Xu Xuan Yang Xiu-An Yang Lei Zhou Tie-Zheng Liu Zusen Fan Tao Jiang 
YfiBNR is a recently identified bis-（3＇-5＇）-cyclic dimeric GMP （c-di-GMP） signaling system in opportunistic pathogens. It is a key regulator of biofilm formation, which is correlated with prolonged persistence o...
关键词：the YfiBNR system C-DI-GMP Vitamin B6 L-Trp peptidoglycan layer bioflim formation 
Potentiating activity of luteolin on membrane permeabilizing agent and ATPase inhibitor against methicillin-resistant Staphylococcus aureus被引量：4
《Asian Pacific Journal of Tropical Medicine》2016年第1期16-19,共4页Dae-Ki Joung Young-Seob Lee Sin-Hee Han Sang-Won Lee Seon-Woo Cha Su-Hyun Mun Ryong Kong Ok-Hwa Kang Ho-Jun Song Dong-Won Shin Dong-Yeul Kwon 
supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF);funded by the Ministry of Educatio(2013060380);the Korea governmen(MSIP)(2008-0062484);Cooperative Research Program for Agriculture Science&Technology Development(Project No.PJ00962201);Rural Development Administration,Republic of Korea
Objective:To investigate the mechanism of antibacterial activity of luteoiin(LUT) against methicillin-resistant Staphylococcus aureus(MRSA).Methods:The mechanism of anti-MRSA activity of LUT was analyzed by the viabil...
关键词：Iuteolin METHICILLIN-RESISTANT Staphylococcus aureus MEMBRANE permeabilizing AGENT ATPASE INHIBITOR PEPTIDOGLYCAN 
Advances of bacterial transferase Mra Y and its inhibitors被引量：1
《Journal of Chinese Pharmaceutical Sciences》2015年第3期137-147,共11页金媛媛 刘娟娟 冯晓洲 李亚东 汪康游 孙婉 田喜凤 杨兆勇 
National Natural Science Foundation of China(Grant No.81273414 and Grant No.81321004);NSFC-NIH International Cooperation and Exchange Programs(Grant No.81261120417,2012-2013)
The phospho-mur NAc-pentapeptide translocase（Mra Y, translocase I） is a good target for the development of new antibiotics as it is ubiquitous and essential for bacterial growth. Furthermore, several inhibitors targ...
关键词：PEPTIDOGLYCAN Mra Y Antibiotic Structure-activity relationships 
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