基于^(18)F-FDG PET及主观认知下降问卷-9诊断主观认知下降  

^(18)F-FDG PET and 9-item subjective cognitive decline questionnaire for diagnosing subjective cognitive decline

作　　者：毕晟 闫少珍 齐志刚[1,2,3] 马杰 杨宏伟[1,2,3] 韩璎 卢洁[1,2,3] BI Sheng;YAN Shaozhen;QI Zhigang;MA Jie;YANG Hongwei;HAN Ying;LU Jie(Department of Radiology and Nuclear Medicine,Capital Medical University,Beijing 100053,China;Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics,Beijing 100053,China;Key Laboratory of Neurodegenerative Diseases,Ministry of Education,Beijing 100053,China;Department of Neurology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]首都医科大学宣武医院放射与核医学科,北京100053 [2]磁共振成像脑信息学北京市重点实验室,北京100053 [3]神经变性病教育部重点实验室,北京100053 [4]首都医科大学宣武医院神经内科,北京100053

出　　处：《中国医学影像技术》2024年第3期332-336,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家重点研发计划(2022YFC2406900);北京市科技计划项目(Z201100005520018);国家自然科学基金(82102010)。

摘　　要：目的观察基于^(18)F-FDG PET及主观认知下降问卷-9(SCD-Q9)诊断主观认知下降(SCD)的价值。方法回顾性分析50例SCD患者(SCD组)及49名健康人(对照组)头颅^(18)F-FDG PET及主观认知下降问卷-9(SCD-Q9)评估结果;对PET图像行全脑体素定量分析,以脑桥为参考计算标准摄取值比值(SUVR),观察SCD组葡萄糖代谢模式,分析SCD组SUVR减低脑区,评估SUVR减低联合SCD-Q9诊断SCD的价值。结果相比对照组,SCD组左内侧额上回及右侧额上回SUVR显著减低、左侧距状回SUVR显著升高(GRF校正,体素水平P均<0.01,团簇水平P均<0.05)。以左内侧额上回+右侧额上回SUVR联合诊断SCD的敏感度、特异度及曲线下面积(AUC)分别为54.00%、77.60%及0.660,进一步联合SCD-Q9分别为86.00%、75.50%及0.840,其间AUC差异有统计学意义(P<0.05)。结论^(18)F-FDG PET脑代谢显像可显示SCD脑代谢异常模式;联合SCD-Q9有助于诊断SCD。Objective To observe the value of ^(18)F-FDG PET and 9-item subjective cognitive decline questionnaire(SCD-Q9)for diagnosing subjective cognitive decline(SCD).Methods Data of ^(18)F-FDG PET images as well as evaluation results of SCD-Q9 of 50 SCD patients(SCD group)and 49 healthy subjects(control group)were retrospectively analyzed.Taken the pons as reference,whole-brain voxel quantification was performed to calculate the standard uptake value ratio(SUVR).The abnormal glucose metabolism pattern of SCD was observed,and the diagnostic efficacy of SUVR reduction brain regions combining with SCD-Q9 for SCD was analyzed.Results Compared with control group,SUVR of left medial superior frontal gyrus and right superior frontal gyrus significantly decreased,while of left calcarine increased in SCD group(GRF corrected,all P<0.01 for voxel level,all P<0.05 for cluster level).The sensitivity,specificity and area under the curve(AUC)of left medial superior frontal gyrus and right superior frontal gyrus for diagnosing SCD was 54.00%,77.60%and 0.660,respectively,while combining with SCD-Q9 was 86.00%,75.50%and 0.840,respectively,with significantly different AUC(P<0.05).Conclusion ^(18)F-FDG PET brain metabolism imaging could display abnormal metabolic patterns of SCD,which combining with SCD-Q9 was helpful for diagnosing SCD.

关 键 词：认知障碍 阿尔茨海默病 正电子发射断层显像 

分 类 号：R742[医药卫生—神经病学与精神病学] R817.4[医药卫生—临床医学]