乳酸化修饰在炎性反应和癌症发生中作用的研究进展  

Role of lactylation in inflammatory reaction and carcinogenesis

作　　者：赵蓝 高文蔚[1] ZHAO Lan;GAO Wenwei(Department of Critical Care Medicine,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院重症医学科,湖北武汉430060

出　　处：《中华实用诊断与治疗杂志》2024年第3期313-316,共4页Journal of Chinese Practical Diagnosis and Therapy

基　　金：国家自然科学基金(82102295)。

摘　　要：乳酸在糖代谢过程中发挥重要作用,既参与糖酵解,又是能量合成的底物,同时具备信号分子功能。乳酸化修饰作为一种新兴的翻译后修饰方式,受到乳酸和糖酵解的调控,参与多种生理病理过程。本文就蛋白质乳酸化修饰的分子机制及其在炎性反应和癌症发生中作用的研究进展作一综述。Lactate is a crucial participant in glucose metabolism,engaging in glycolysis and serving as a substrate for energy synthesis,while also functioning as a signaling molecule.Furthermore,lactylation,an emerging post-translational modification,is regulated by lactate and glycolysis,and significantly contributes to a wide array of physiological and pathological phenomena.This paper reviews the research progress of intricate molecular mechanisms underlying protein lactylation and its consequential impact on inflammatory reaction and carcinogenesis.

关 键 词：乳酸 乳酸化 翻译后修饰 炎性反应 癌症 

分 类 号：R730.2[医药卫生—肿瘤]