黑斑息肉综合征的诊治研究进展  

Research progress in the diagnosis and treatment of Peutz-Jeghers syndrome

作　　者：张臻 樊志敏 汤艳 Zhang Zhen;Fan Zhimin;Tang Yan(Department of Anorectum,Nanjing Hospital of Traditional Chinese Medicine affiliated to Nanjing University of Chinese Medicine,Nanjing 210022,Jiangsu,China;Jiangsu Provincial Clinical Medical Innovation Center for Colorectal Diseases,Nanjing 210022,Jiangsu,China)

机构地区：[1]南京中医药大学附属南京中医院肛肠科,江苏南京210022 [2]江苏省中医肛肠疾病临床医学创新中心,江苏南京210022

出　　处：《结直肠肛门外科》2024年第1期119-122,共4页Journal of Colorectal & Anal Surgery

基　　金：江苏省重点研发计划(社会发展)项目(BE2021611)。

摘　　要：黑斑息肉综合征(Peutz-Jeghers syndrome,PJS)是一种罕见的常染色体显性遗传疾病,常因引起急、慢性并发症或多种癌症而危及患者生命。近年来,随着国内外对PJS认识和临床实践的不断深入,针对该病的诊断、监测和治疗已经有了较大进展。中医通过息肉的病因病机、患者体质及发病特点辨证论治,亦有明显临床疗效。但我国目前尚无PJS诊治共识,故本文对PJS的临床表现、诊断和鉴别诊断、临床监测与治疗进行综述,以期提高临床医师对PJS的认识和诊治能力,探究有效且更安全的中西医靶向药物,并为制定中国PJS诊治共识及用药建议提供参考。Peutz-Jeghers syndrome(PJS)is a rare autosomal dominant genetic disease that often poses a threat to the life of patients due to acute and chronic complications or various cancers.In recent years,with the deepening of understanding and clinical practice of PJS at home and abroad,significant progress has been made in the diagnosis,monitoring,and treatment of this disease.Traditional Chinese Medicine has also demonstrated obvious clinical effects through syndrome differentiation and treatment based on the etiology and pathogenesis of polyps,patient constitution,and disease characteristics.However,there is currently no consensus on the diagnosis and treatment of PJS in China.Therefore,this article reviews the clinical manifestations,diagnosis and differential diagnosis,clinical monitoring and treatment of PJS,aiming to improve clinicians’understanding and diagnosis and treatment abilities of PJS,explore effective and safer targeted drugs combining traditional Chinese and Western medicine,and provide references for the development of consensus and medication suggestions for the diagnosis and treatment of PJS in China.

关 键 词：黑斑息肉综合征 错构瘤性息肉 癌症风险监测 

分 类 号：R596[医药卫生—内科学]