ACE2 rs2074192位点多态性与非乙醇性脂肪性肝病易感性的相关性  

Association of ACE2 rs2074192 polymorphism with susceptibility to nonalcoholic fatty liver disease

作　　者：赵守林[1] 张梅[1] 赵真真 陈立震 宣世英[1] ZHAO Shoulin;ZHANG Mei;ZHAO Zhenzhen;CHEN Lizhen;XUAN Shiying(Department of Infectious Diseases,Qingdao Municipal Hospital Affiliated to Qingdao University,Qingdao 266071,China)

机构地区：[1]青岛大学附属青岛市市立医院感染性疾病科,山东青岛266071 [2]青岛大学附属青岛市市立医院临床研究中心,山东青岛266071

出　　处：《青岛大学学报（医学版）》2024年第1期39-42,共4页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金面上项目(32171277)。

摘　　要：目的探讨青岛地区人群血管紧张素转化酶2(ACE2)rs2074192位点多态性与非乙醇性脂肪性肝病(NAFLD)易感性的相关性。方法研究纳入NAFLD病人208例,健康查体者105例。收集受试者的血液标本,提取DNA,应用多聚酶链反应(PCR)检测ACE2基因rs2074192位点的基因型,比较ACE2 rs2074192位点基因型及等位基因频率在NAFLD组及对照组的分布差异。同时收集受试者的临床资料及实验室生化检查结果,比较不同基因型病人临床资料及实验室生化结果的差异。结果NAFLD组和对照组ACE2 rs2074192位点的基因型与等位基因分布差异均无统计学意义(P>0.05)。ACE2 rs2074192位点T等位基因女性携带者体质量指数高于未携带者,T等位基因男性携带者血清葡萄糖水平低于未携带者(t=-2.613、-3.195,P<0.05)。结论青岛地区人群ACE2 rs2074192位点多态性与NAFLD易感性无明显相关性。Objective To investigate the relationship between the polymorphism at rs2074192 of the angiotensin-converting enzyme 2 gene(ACE2)and susceptibility to nonalcoholic fatty liver disease(NAFLD)in a population of Qingdao Province,China.Methods A total of 208 patients with NAFLD and 105 healthy subjects were included.DNA was extracted from their blood samples to determine the genotype of rs2074192 of the ACE2 gene by using polymerase chain reaction.The frequency distributions of ACE2 rs2074192 genotypes and alleles were compared between the NAFLD group and control group.The clinical data and laboratory results of patients carrying different genotypes were compared.Results There were no significant differences in the distributions of ACE2 rs2074192 genotypes and alleles between the NAFLD group and the control group(P>0.05).Among female patients,the body mass index was significantly higher in T allele carriers than in those not carrying the T allele at ACE2 rs2074192(t=-2.613,P<0.05).Among male patients,serum glucose level was significantly lower in T allele carriers than in those not harboring the T allele(t=-3.195,P<0.05).Conclusion There was no significant association of ACE2 rs2074192 polymorphism with NAFLD susceptibility in the Qingdao population.

关 键 词：非酒精性脂肪性肝病 多态性 限制性片段长度 血管紧张素转换酶2 疾病遗传易感性 

分 类 号：R575.5[医药卫生—消化系统]