Enhanced Beta2-band Oscillations Denote Auditory Hallucination in Schizophrenia Patients and a Monkey Model of Psychosis  

作　　者：Shuo Ma Tianzhen Chen Wenjun Jia Jie Liu Shihan Ding Puzhe Li Hong Gan Dapeng Zhang Shuxin Shao Mu-Ming Poo Min Zhao Bomin Sun Jian Jiang 

机构地区：[1]Department of Neurosurgery,Ruijin Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai,200020,China [2]Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Shanghai,200030,China [3]Shanghai Center for Brain Science and Brain-inspired Technology,Lingang Laboratory,Shanghai,201602,China [4]University of California at Berkeley,Berkeley,CA,94720,USA [5]School of Life Science and Technology,ShanghaiTech University,Shanghai,201210,China [6]Institute of Neuroscience,CAS Center for Excellence in Brain Science and Intelligence Technology,CAS Key Laboratory of Primate Neurobiology,State Key Laboratory of Neuroscience,Chinese Academy of Sciences,Shanghai,200031,China [7]Shanghai Center for Brain Science and Brain-Inspired Intelligence Technology,Lingang Laboratory,Shanghai,201210,China [8]Fuyang Third People’s Hospital,Fuyang Mental Health Center,Fuyang,236052,China [9]Shanghai Key Laboratory of Psychotic Disorders,Shanghai,200030,China [10]Institute of Psychological and Behavioral Science,Shanghai Jiao Tong University,Shanghai,200030,China [11]Shanghai Quanlan Technology Co.,Ltd,Shanghai,201602,China

出　　处：《Neuroscience Bulletin》2024年第3期325-338,共14页神经科学通报（英文版）

基　　金：supported by a Shanghai Municipal Science and Technology Major Project(2021SHZDZX,E154N41011);the Lingang Lab Program(LG2021050202 and LG2021060301);the National Nature Science Foundation(82130041);the Shanghai Rising-star Cultivation Program(22YF1439200).

摘　　要：An electroencephalographic(EEG)signature of auditory hallucinations(AHs)is important for facilitating the diagnosis and treatment of AHs in schizophrenia.We recorded EEG from 25 schizophrenia patients with recurrent AHs.During the period of AHs,EEG recordings exhibited significantly elevated beta2-band power in the temporal region,as compared to those recorded in the absence of AHs or during stimulation with verbal sounds.We further generated methamphetamine-treated rhesus monkeys exhibiting psychosis-like behaviors,including repetitive sudden searching actions in the absence of external intrusion,suggesting the occurrence of AHs.Epidural EEG beta2-band power in the temporal region of these monkeys was enhanced immediately after methamphetamine treatment and positively correlated with the frequency of sudden searching actions.Thus,the enhancement of temporal beta2-band oscillations represents a signature for AHs in both patients and a monkey model of psychosis,and this monkey model can be used for developing closed-loop neuromodulation approaches for the treatment of refractory AHs in schizophrenia.

关 键 词：SCHIZOPHRENIA Auditory hallucinations Non-human primate METHAMPHETAMINE ELECTROENCEPHALOGRAPHY 

分 类 号：R749.3[医药卫生—神经病学与精神病学]