Targeting NAD Metabolism for the Therapy of Age-Related Neurodegenerative Diseases  

作　　者：Feifei Li Chou Wu Gelin Wang 

机构地区：[1]School of Pharmaceutical Sciences,Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology,Tsinghua University,Beijing 100084,China [2]Tsinghua-Peking Joint Center for Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《Neuroscience Bulletin》2024年第2期218-240,共23页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China(91949101 and 81872874);the Tsinghua-Peking Center for Life Sciences,the Beijing Advanced Innovation Center for Structural Biology,the Tsinghua-Toyota Joint Research Fund,and the Tsinghua University Initiative Scientific Research Program.

摘　　要：As the aging population continues to grow rapidly, age-related diseases are becoming an increasing burden on the healthcare system and a major concern for the well-being of elderly individuals. While aging is an inevitable process for all humans, it can be slowed down and age-related diseases can be treated or alleviated. Nicotinamide adenine dinucleotide (NAD) is a critical coenzyme or cofactor that plays a central role in metabolism and is involved in various cellular processes including the maintenance of metabolic homeostasis, post-translational protein modifications, DNA repair, and immune responses. As individuals age, their NAD levels decline, and this decrease has been suggested to be a contributing factor to the development of numerous age-related diseases, such as cancer, diabetes, cardiovascular diseases, and neurodegenerative diseases. In pursuit of healthy aging, researchers have investigated approaches to boost or maintain NAD levels. Here, we provide an overview of NAD metabolism and the role of NAD in age-related diseases and summarize recent progress in the development of strategies that target NAD metabolism for the treatment of age-related diseases, particularly neurodegenerative diseases.

关 键 词：Ageing NEUROPROTECTION NAD metabolism Therapeutic strategy Neurodegenerative diseases 

分 类 号：R749.16[医药卫生—神经病学与精神病学]