腰骶丛MRN在腓骨肌萎缩症1A评估中的作用及表现分析  

Utility of Lumbosacral Plexus MR Neurography in the Assessment of Charcot-Marie-Tooth Disease 1A and Imaging Feature Analysis

作　　者：孙兴文 周广金[1] 刘小璇[2] 朱雨辰 樊东升[2] 袁慧书[1] 张立华[1] SUN Xingwen;ZHOU Guangjin;LIU Xiaoxuan(Department of Radiology,Peking University Third Hospital,Beijing 100191,P.R.China)

机构地区：[1]北京大学第三医院放射科,100191 [2]北京大学第三医院神经内科,100191

出　　处：《临床放射学杂志》2024年第2期169-173,共5页Journal of Clinical Radiology

摘　　要：目的探讨腓骨肌萎缩症(CMT)1A的腰骶丛神经影像的表现并分析神经成像在该病评估及诊断中的应用价值。方法对46例临床确诊的CMT1A患者的腰骶丛神经成像进行分析,分析神经形态、信号特点并测定脊神经L_(4、5),股神经及坐骨神经的直径与正常组进行比较,并与电生理、临床特征及评分进行相关性分析。结果受累神经主要表现为双侧对称性增粗(93.5%),高达65.2%的表现为中等程度以上的增粗;67.4%增粗的神经在T_(2)WI脂肪抑制序列伴信号增高;增粗神经周围26.1%可伴囊肿形成;23.9%伴马尾神经增粗;神经直径与电生理、临床评分以及肌力存在显著相关性。结论腰骶丛神经成像可准确评估CMT1A的周围神经的形态及信号特点,可用于临床诊断及评估。Objective To investigate MR neurography features of Charcot-Marie-Tooth Disease type 1A(CMT1A)and analyze the value of MR neurography in the diagnosis and assessment of the disease.Methods We analyzed the MR neurography features of 46 CMT1A cases.The morphology,signal intensity and nerve diameter of L_(4、5) nerve roots,the femoral nerve,and the sciatic nerve were assessed and compared with healthy controls.Correlations of nerve diameter with electrophysiological results,clinical variables and scores were analyzed.Results The affected nerves mainly presented as symmetric thickening(43,93.5%).65.2% cases showed moderate to prominent nerve thickening.The signal intensity in fatsuppressed T_(2) imaging was increased in 67.4 %of the thickened nerves.26.1% of the thickened nerves were accompanied by perineural cyst formation.23.9% of the cases showed thickening of the cauda equina.Significant correlations were observed between nerve diameters and electrophysiological results,clinical variables and scores.Conclusion Lumbosacral plexus MR neurography could accurately assess the morphological features and signal changesof affected nerves in CMT1A.It could be used for clinical diagnosis and assessment of the disease.

关 键 词：周围神经成像 腓骨肌萎缩症 磁共振成像 

分 类 号：R745[医药卫生—神经病学与精神病学]