MicroRNAs in hepatocellular carcinoma treatment:Charting the path forward  

作　　者：Hong T Lin Antonio F Alvarez Castaneda Somashekar G Krishna Khalid Mumtaz 

机构地区：[1]Division of Gastroenterology,Hepatology and Nutrition,Department of Medicine,The Ohio State University Wexner Medical Center,Columbus,OH 43210,United States

出　　处：《World Journal of Gastroenterology》2024年第11期1470-1474,共5页世界胃肠病学杂志（英文版）

摘　　要：MicroRNAs(miRNAs)are recognized for their involvement in the regulation of gene expression and exhibit significant potential in both the prognostic assessment and treatment of hepatocellular carcinoma(HCC).HCC,like other tumors,seldom occurs in isolation;instead,it evolves within a microenvironment featuring oncogenic and tumor-suppressive elements.When combined with suitable delivery vehicles,miRNA technology provides the capability to directly engage with these elements,thereby hindering tumor formation and progression.Ongoing research in this domain holds the promise of enabling a more efficacious and multi-modal treatment approach for HCC in the near future.

关 键 词：Hepatocellular carcinoma Tumor microenvironment MicroRNA Mesenchymal stem cell EXOSOME 

分 类 号：R735.7[医药卫生—肿瘤]