O-linkedβ-N-acetylglucosaminylation may be a key regulatory factor in promoting osteogenic differentiation of bone marrow mesenchymal stromal cells  

作　　者：Xu-Chang Zhou Guo-Xin Ni 

机构地区：[1]School of Sport Medicine and Rehabilitation,Beijing Sport University,Beijing 100084,China [2]Department of Rehabilitation Medicine,The First Affiliated Hospital of Xiamen University,Xiamen 361003,Fujian Province,China

出　　处：《World Journal of Stem Cells》2024年第3期228-231,共4页世界干细胞杂志（英文版）（电子版）

摘　　要：Cumulative evidence suggests that O-linkedβ-N-acetylglucosaminylation(OGlcNAcylation)plays an important regulatory role in pathophysiological processes.Although the regulatory mechanisms of O-GlcNAcylation in tumors have been gradually elucidated,the potential mechanisms of O-GlcNAcylation in bone metabolism,particularly,in the osteogenic differentiation of bone marrow mesenchymal stromal cells(BMSCs)remains unexplored.In this study,the literature related to O-GlcNAcylation and BMSC osteogenic differentiation was reviewed,assuming that it could trigger more scholars to focus on research related to OGlcNAcylation and bone metabolism and provide insights into the development of novel therapeutic targets for bone metabolism disorders such as osteoporosis.

关 键 词：O-GLCNACYLATION Osteogenic differentiation Bone marrow mesenchymal stromal cells OSTEOPOROSIS 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]