Clinical and socioeconomic determinants of survival in biliary tract adenocarcinomas  

作　　者：Laura Sahyoun Kay Chen Cynthia Tsay George Chen Petr Protiva 

机构地区：[1]Department of Gastroenterology and Hepatology,Weill Cornell Medicine,New York,NY 10065,United States [2]Gastroenterology Section,Jennifer Moreno VA San Diego Healthcare System,San Diego,CA 92161,United States [3]Division of Gastroenterology,Department of Medicine,University of California San Diego,La Jolla,CA 92093,United States [4]Department of Gastroenterology and Hepatology,John Hopkins Hospital,Baltimore,MD 21287,United States [5]Department of Digestive Diseases,Yale New Haven Hospital,New Haven,CT 06520,United States [6]Department of Gastroenterology,VA Connecticut Health Care System,West Haven,CT 06516,United States

出　　处：《World Journal of Gastrointestinal Oncology》2024年第4期1374-1383,共10页世界胃肠肿瘤学杂志（英文版）（电子版）

摘　　要：BACKGROUND Despite advances in detection and treatments,biliary tract cancers continue to have poor survival outcomes.Currently,there is limited data investigating the significance of socioeconomic status,race/ethnicity,and environmental factors in biliary tract cancer survival.Data from the Surveillance,Epidemiology,and End Results database for biliary and gallbladder adenocarcinomas were extracted from 1975 to 2016.Socioe-conomic data included smoking,poverty level,education,adjusted household income,and percentage of foreign-born persons and urban population.Survival was calculated with Cox proportional hazards models for death in the 5-year period following diagnosis.RESULTS Our study included 15883 gallbladder,11466 intrahepatic biliary,12869 extrahepatic biliary and 7268 ampulla of Vater adenocarcinoma cases.When analyzing county-specific demographics,patients from counties with higher incomes were associated with higher survival rates[hazard ratio(HR)=0.97,P<0.05].Similarly,counties with a higher percentage of patients with a college level education and counties with a higher urban population had higher 5-year survival rates(HR=0.96,P=0.002 and HR=0.97,P=0.004,respectively).CONCLUSION Worse survival outcomes were observed in lower income counties while higher income and education level were associated with higher 5-year overall survival among gallbladder and biliary malignancies.

关 键 词：Biliary tract cancers SURVIVAL Outcomes research Socioeconomic factors Healthcare disparities 

分 类 号：R735[医药卫生—肿瘤]