Expression,clinicopathologic,and prognostic significance of MMP15 in operable pancreatic ductal adenocarcinoma  

作　　者：Wen-Jing Liu Jian-Zhou Liu Wei-Xun Zhou Li Zhou Jun-Chao Guo 

机构地区：[1]Department of General Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing,China [2]Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences/Peking Union Medical College,Beijing,China

出　　处：《Journal of Pancreatology》2023年第3期96-100,共5页胰腺病学杂志（英文）

基　　金：kindly supported by the National Natural Science Foundation(81402027 and 81972324);the Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2016-I2M-3-019),China.

摘　　要：Objective:Matrix metalloproteinase 15(MMP15)has been previously reported to be involved in many cancers.However,its expression pattern in pancreatic ductal adenocarcinoma(PDAC)remains contradictory.In addition,its clinicopathologic and prog-nostic significance in this malignancy has not been elucidated.Methods:Expression of MMP15 was immunohistochemically detected in a tissue microarray of formalin-fixed paraffin-em-bedded samples from 95 patients of PDAC after surgery.Its expression pattern and relations with clinicopathologic factors and disease-specific survival(DSS)were then evaluated.Finally,its expression and prognostic value were measured in the on-line publically available database,GEPIA,using TCGA data.Results:In comparison of all samples and 75 paired ones,MMP15 expression in tumor tissues was all significantly higher than that in para-tumor ones(P=.037 and.016).Furthermore,tumoral MMP15 expression was associated with peri-neural invasion.Survival anal-ysis showed that patients with high tumoral MMP15 expression had significantly poorer DSS than those with low MMP15 expression(P=.0059).In univariate and multivariate Cox regression tests,tumoral MMP15 expression was all significantly predictive for DSS.In the on-line publically available GEPIA database,MMP15 was also overexpressed in PDAC,but was not found to be prognostic.Conclusion:Our results indicated that MMP15 expression was elevated in operable PDAC and might have a prognostic impact.

关 键 词：EXPRESSION Matrix metalloproteinase 15 Pancreatic ductal adenocarcinoma PROGNOSIS 

分 类 号：R735.9[医药卫生—肿瘤]