Zingiber officinale(Ginger)Methanol Extract Abates Kidney Dysfunction in Mice Co-exposed to Sub-chronic Alcohol Intoxication and Post-traumatic Stress Disorder  

作　　者：Olusegun G.Adebayo Benneth Ben-Azu Egwonor Akpofure Modo U.Emmanuel Iheanyichukwu Wopara Wadioni Aduema Lawrence Dayo Adedayo Jude Ijuo Abeje 

机构地区：[1]Neurosciences and Oral Physiology Unit,Department of Physiology,Faculty of Basic Medical Sciences,College of Medicine,University of Ibadan,Ibadan 200005,Nigeria [2]Department of Pharmacology,Faculty of Basic Medical Sciences,College of Health Sciences,Delta State University,Abraka,Delta State,Nigeria [3]Department of Medicine,Evercare Hospital,Lekki,Lagos State 105102,Nigeria [4]Department of Biochemistry,Faculty of Basic Medical Sciences,PAMO University of Medical Sciences,Port-Harcourt,River State 500272,Nigeria [5]Department of Biochemistry,Faculty of Sciences,River State University,Port Harcourt,River State 500004,Nigeria [6]Department of Physiology,Faculty of Basic Medical Sciences,Bayelsa Medical University,Yenagoa,Bayelsa State 178,Nigeria [7]Neurophysiology Division,Physiology Programme,College of Health Science,Bowen University,Iwo 232101,Nigeria

出　　处：《Clinical Complementary Medicine and Pharmacology》2023年第4期79-90,共12页临床补充医学和药理学（英文）

摘　　要：Background:Increasing number of people globally gives in to indiscriminate consumption of excess alcohol as a coping mechanism to relieve any form of physical or psychological stress.Previously,ethnomedicinal use of Zingiber officinale Roscoe(Ginger)have been shown to exhibit broad range of pharmacological benefits but no data has reported the phytotherapeutic treatment of Zingiber officinale methanol extract(MEZO)on alcohol-use disorder(AUD)and post-traumatic stress disorder(PTSD)-induced oxidative and inflammatory stress relevant to disruption of kidney functions in animal model.Objective:To investigate the protective effect of MEZO on kidney-oxidative and inflammatory biomarkers in sub-chronic alcohol exacerbation of PTSD symptoms in mice.Methods:Male Swiss mice were administered 30%ethanol for two weeks and thereafter introduced to single pro-longed stress to induce AUD and PTSD respectively prior to post-treatment with MEZO and vitamin C.Markers of oxidative stress,inflammatory cytokines,kidney functions,HPA-axis signaling molecules,vasodilator substance,and histopathology of the kidney were evaluated.Results:Sub-chronic alcohol intoxication heightened PTSD-induced oxido-inflammatory stress,altered the kidney function indices and HPA-axis,and reduced nitric oxide production,which were ameliorated by the phytother-apeutic treatment with MEZO.Furthermore,severe degeneration and atrophy of renal tubules were observed.Meanwhile,MEZO interventions strongly abated all these effects.Conclusions:Herein,the study shows that phytotherapeutic treatment with MEZO prevents the damaging effects of co-exposure to sub-chronic alcohol intoxication and PTSD.

关 键 词：Zingiber officinale KIDNEY ALCOHOL Single prolonged stress Oxidative stress 

分 类 号：R692[医药卫生—泌尿科学]