Therapeutic Benefits of Vernonia amygdalina in the Treatment of Inflammation and Its Associated Diseases  

作　　者：Du-Bois Asante Gideon Akuamoah Wiafe Korantema Mawuena Tsegah Nelson Kwabla Domey 

机构地区：[1]Department of Forensic Sciences,School of Biological Sciences,College of Agriculture and Natural Sciences,University of Cape Coast,PMB,Cape Coast,Ghana [2]Department of Biomedical Sciences,School of Allied Health Sciences,College Health and Allied Sciences,University of Cape Coast,PMB,Cape Coast,Ghana [3]School of Medical Sciences,College Health and Allied Sciences,University of Cape Coast,PMB,Cape Coast,Ghana

出　　处：《Clinical Complementary Medicine and Pharmacology》2024年第1期44-53,共10页临床补充医学和药理学（英文）

摘　　要：Background:In the presence of a stimulus that disrupts homeostasis,the body elicits a response known as in-flammation.The inflammatory response is expected to restore the normal functioning of the body and initiate healing where necessary.However,the persistent activity of acute inflammation results in chronic inflammation which causes adverse consequences associated with diseases such as diabetes and arthritis.In traditional medical practice,Vernonia amygdalina is used to treat several ailments such as malaria,fever,diabetes,and inflammatory conditions such as those related to pain and swelling.Objective:This review seeks to explore and discuss the therapeutic benefits of V.amygdalina in the treatment of inflammation and its associated diseases.Methods:We reviewed the scientific literature indexed in PubMed,ScienceDirect and Springer,and discussed the reported anti-inflammatory properties of V.amygdalina and its curative activity in inflammation-associated diseases.Results:A total of 30 published articles were identified describing the therapeutic effect of V.amygdalina in predominately experimental models.The anti-inflammatory properties of V.amygdalina have been linked to the presence of bioactive phytoconstituents predominantly present in the leaves of the plant.Conclusions:Multiple studies have demonstrated that the aqueous and ethanolic extracts of V.amygdalina can inhibit the production of proinflammatory cytokines and enzymes in inflammatory cells,reducing inflammation and its associated complications.We critically appraise the current evidence,and discuss the potential use of this medicinal plant in the treatment of inflammatory conditions.

关 键 词：Vernonia amygdalina INFLAMMATION CYTOKINES Wound healing ANALGESIC ANTIPYRETIC 

分 类 号：R95[医药卫生—药学]