Tumor microenvironment-dependent epigenetic imprinting in the vasculature predicts colon cancer outcome  

作　　者：Elisabeth Naschberger Maximilian Fuchs Nicholas Dickel Meik Kunz Bernt Popp Charles Gwellem Anchang Richard Demmler Yanmin Lyu Steffen Uebe Arif Bülent Ekici Carol Immanuel Geppert Arndt Hartmann Christian Flierl Katja Petter Tobias Gass Simon Völkl Michael Scharl Andreas Ramming Claudia Günther Susanne Merkel Vera Simone Schellerer Michael Stürzl 

机构地区：[1]Division of Molecular and Experimental Surgery,Translational Research Center,Universitätsklinikum Erlangen,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Bavaria,Germany [2]Comprehensive Cancer Center Erlangen-EMN (CCC ER-EMN),Erlangen,Bavaria,Germany [3]Chair of Medical Informatics,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Bavaria,Germany [4]Fraunhofer Institute of Toxicology and Experimental Medicine,Lower saxony,Hannover,Germany [5]Institute of Human Genetics,Universitätsklinikum Erlangen,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Bavaria,Germany [6]Department of Medicine 3,Universitätsklinikum Erlangen,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Bavaria,Germany [7]Institute of Pathology,Universitätsklinikum Erlangen,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Bavaria,Germany [8]Department of Internal Medicine 5 – Hematology and Oncology,Universitätsklinikum Erlangen,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Bavaria,Germany [9]Department of Gastroenterology and Hepatology,University Hospital Zurich,University of Zurich,Canton Zurich,Zurich,Switzerland [10]Department of Medicine 1,Universitätsklinikum Erlangen,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Bavaria,Germany [11]Department of Surgery,Universitätsklinikum Erlangen,Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU),Erlangen,Bavaria,Germany

出　　处：《Cancer Communications》2023年第11期1280-1285,共6页癌症通讯（英文）

基　　金：German Research Foundation.Grant Numbers:FOR2438,280163318;DFGSFB/TRR241,375876048;DFGSTU238/10-1,437201724;DFGTRR305,429280966;DFG-NOTICE,493624887 Interdisciplinary Center for Clinical Research Programm zur Förderung von Corona-Forschungsprojekten W.Lutz Stiftung Forschungsstiftung Medizin am Universitätsklinikum Erlangen German Federal Ministry of Education and Research.Grant Numbers:01KT1801,031L0262C Chinese scholarship program。

摘　　要：Dear Editor,Tumor microenvironment(TME)-dependent stromal cell plasticity governs tumor development and therapy response.Tumor endothelial cells(TECs)are a major cellular component in this context[1].In colorectal carcinoma(CRC),the stromal cell-dependent impact of the TME is illustrated by an improved survival depending on an interferon(IFN)-γ-dominated Th1-like TME associated with high T-cell density[2]and suppressed angiogenesis[3,4].Cellular transcriptional memory is reported in cell lines after repeated exposure to IFN-γin vitro[5],suggesting that a Th1-like TME may also exert stable imprinting effects in vivo.Here,we investigated whether TME-dependent transcriptional imprinting in TECs from CRC patients can be exploited to retrieve clinically relevant signatures predicting outcomes.

关 键 词：IMPRINTING COLON INTERFERON 

分 类 号：R735.35[医药卫生—肿瘤]