Acatulides A-G,neuroprotective macrolides from Acaulium album H-JQSF  

作　　者：Zhi-Wu Tong Ting-Ting Wang Pei Yang Jia-Lin Sun Chen-Peng Zhang Salman Khan Xin-Cun Wang Rui-Hua Jiao Hui-Ming Ge Wen-Ying Zhuang Gang Hu Ren Xiang Tan 

机构地区：[1]State Key Laboratory of Pharmaceutical Biotechnology,Institute of Functional Biomolecules,Nanjing University,Nanjing 210023,China [2]State Key Laboratory Cultivation Base for TCM Quality and Efficacy,Nanjing University of Chinese Medicine,Nanjing 210023,China [3]Insitute of Microbiology,Chinese Academy of Sciences,Beijing 100101,China

出　　处：《Chinese Chemical Letters》2024年第3期379-383,共5页中国化学快报（英文版）

基　　金：co-financed by the grants from National Nature Science Foundation of China(Nos.81991523 and 81991524);National Science and Technology Innovation 2030-Major Program of“Brain Science and Brain-Like Research”(No.2022ZD0211804)。

摘　　要：Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and superficial.Here we present the chemical characterization of acatulides A-G(1-7)as architecturally unprecedented macrolides from the solid-state culture of Acaulium album H-JQSF,an arthropod-associated fungus.The acatulide structures were elucidated by spectroscopic analysis,modified Mosher's method and single-crystal X-ray diffraction.The plausible biosynthetic pathways for compounds 1-4 are proposed.Interestingly,acatulides B-D(2-4)and G(7)were demonstrated to be neuroprotective against the 1-methyl-4-phenylpyridinium(MPP+)-induced damage to SH-SY5Y cells and nematode Caenorhabditis elegans(C.elegans).

关 键 词：Acaulium album MACROLIDES Acatulides A–G Mosher’s method NEUROPROTECTIVE 

分 类 号：TQ460.1[化学工程—制药化工]