BACKGROUND Diffuse panbronchiolitis(DPB)is a rare,chronic inflammatory lung disease mar-ked by chronic cough,breathlessness,and preceding sinusitis.Symptoms often persist for years and can be misdiagnosed as asthma,pa...
supported by the National Natural Science Foundation of China(82204275,82160653,and 22267006);Natural Science Foundation of Hainan Province(323Ms014 and 222QN303);Fundamental Research Funds for Hainan University(KYQD(ZR)-22088 and KYQD(ZR)-21089)。
Four polycyclic ten-membered lactones possessing unprecedented 10/6/5 tricyclic ring skeleton,named eutypetides A—D(1—4),and an intriguing polyketide containing a hexahydroisobenzofuran-1(3H)-one motif,named eutypet...
Knowledge Innovation Program of Wuhan-Shugung Project,Grant/Award Number:2023020201020363。
The widespread use of antibiotics has significantly increased their presence in aquatic environments,particularly in sensitive Karst River systems.In this study,the distribution and ecological,human health,and resista...
To evaluate the clinical efficacy and safety of oral versus intravenous macrolide antibacterials in managing pediatric pneumonia attributable to Mycoplasma pneumoniae(MP),we conducted a retrospective analysis of clini...
co-financed by the grants from National Nature Science Foundation of China(Nos.81991523 and 81991524);National Science and Technology Innovation 2030-Major Program of“Brain Science and Brain-Like Research”(No.2022ZD0211804)。
Fungal symbionts co-evolve with hosts and microbial co-inhabitants to acquire an unpredictable potential for producing novel bioactive metabolites,but the knowledge about the topic remains patchy and superficial.Here ...
Background: COVID-19 is a disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Epidemiological data indicated that bacterial complications in COVID-19 would decrease clearance rate of the in...
the"100 Talent Program of Chinese Academy of Sciences";"1000-Youth Talents Plan";ShanghaiYouth Talent,National Science&Technology Major Project"Key New Drug Creation and Manufacturing Program"China(No. 2018ZX09711002–006);Science and Technology Commission of Shanghai Municipality (No. 18431907100);ShanghaiTechnology Innovation Action Plan (No. 18JC1415300);the Research Grants Council of Hong Kong (No. HKUST 16302418) for financial support of this research。
The development of innovative strategies and methods to provide natural product-like macrocycles not accessible by biosynthesis, but endowed with novel bioactivities and simplified structure, is highly desirable. Insp...
Guangdong Provincial Special Fund for Marine Economic Development Project([2020]042);the National Natural Science Foundation of China(41906106);the Guangdong Special Support Program(2019TQ05Y375);Team Project of the Natural Science Foundation of Guangdong Province(2016A030312014);the GDAS_Project of Science and Technology Development(2019GDASYL-0103007);We sincerely thank Mr.Can Li of central laboratory of Southern Medical University for NMR measurements.
Lithocarpins E-G,featuring a rare naturally-occurring highly oxygenated tenellone-macrolide skeleton,were isolated from the culture extract of a marine-derived fungus Phomopsis lithocarpus FS508.Their structures were ...
Prostatitis is a widespread disease associated with pelvic pain syndrome, which is characterized by pelvic pain, various urinary symptoms, and possible sexual dysfunction. An adequate therapy requires schemes for chro...
SARS-CoV-2 is a novel RNA coronavirus responsible of a deadly pandemic: the clinical illness COVID-19. With only one authorized drug for emergency use in critically ill patients: Remdesivir, there is not any other app...