肠道菌群对黄酮类化合物的代谢作用及生物学活性影响研究进展  

Research progress on the metabolic action and biological effects of flavonoids mediated by intestinal flora

作　　者：金杜欣 曹维 赵秀丽 刘瑞 吴满刚[2] 葛庆丰[2] 于海[2] JIN Duxin;CAO Wei;ZHAO Xiuli;LIU Rui;WU Mangang;GE Qingfeng;YU Hai(Guangling College of Yangzhou University,Yangzhou 225000,China;School of Food Science and Engineering,Yangzhou University,Yangzhou 225127,China;School of Public Health,Yangzhou University,Yangzhou 225127,China)

机构地区：[1]扬州大学广陵学院,江苏扬州225000 [2]扬州大学食品科学与工程学院,江苏扬州225127 [3]扬州大学公共卫生学院,江苏扬州225127

出　　处：《食品与发酵工业》2024年第7期324-330,共7页Food and Fermentation Industries

基　　金：江苏省高等学校基础科学(自然科学)研究面上项目(21KJB350021);扬州大学科技创新培育基金项目(135030532)。

摘　　要：黄酮类化合物是广泛存在于日常饮食中、由植物合成的次生代谢产物,具有多重生物学活性,如抗氧化、抗炎、抗癌、抗心血管疾病等。然而,黄酮类化合物的结构特点导致其在体内的生物利用度极低。近年来,研究发现黄酮类化合物能够在肠道菌群的作用下发生代谢转化,一定程度上提高了生物利用度,且其代谢产物具有与母药相似或更高的生物学活性。因此,解析黄酮类化合物在肠道菌群作用下的代谢规律及其代谢产物的生物学活性可为阐释其体内药效机理提供重要的理论参考依据。文章综述了黄酮类化合物在肠道微生物作用下的代谢反应,对黄酮类化合物经体内肠道菌群作用后代谢产物的生物学活性及机制进行相应的讨论,为明确黄酮类化合物在体内发挥生物学活性的有效形式提供理论支撑。Flavonoids are secondary metabolites that are widely found in daily diet and synthesized by plants.They possess multiple biological activities,such as antioxidant,anti-inflammatory,anticancer,and anti-cardiovascular diseases.However,the in vivo bioavailability of flavonoids is very low due to their structural characteristics.Recently,studies have found that flavonoids can undergo metabolic transformation under the action of gut microbiota,and their bioavailability can be improved to a certain extent.Moreover,the gut bacterial transformation products of flavonoids exhibit similar or higher biological activities than their mother drugs.Hence,it can provide important theoretical basis to interpret the in vivo pharmaceutical effect and mechanisms of flavonoids via analyzing the metabolic rules of flavonoids under the action of intestinal flora and studying the biological activities of their metabolites.In this review,the metabolic reactions of flavonoids under the action of gut bacteria are summarized,and biological activities and mechanisms of flavonoids metabolites after fermented by intestinal flora are discussed,which could provide theoretical support for clarifying the effective forms of flavonoids exerting biological activities in in vivo.

关 键 词：黄酮类化合物 肠道菌 代谢反应 转化产物 生物学活性 

分 类 号：TS201.2[轻工技术与工程—食品科学]