The dysfunctional Wnt pathway down-regulates MLH1/SET expression and promotes microsatellite instability and immunotherapy response in colorectal cancer  

作　　者：Jiyan Wang Tao He Qingle Gao Hongkai Chang Xintong Dai Juze Yang Shuangping Liu Shuai Zhang Changliang Shan Chunze Zhang 

机构地区：[1]State Key Laboratory of Medicinal Chemical Biology,College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research,Nankai University,Tianjin 300350,China [2]Departments of Pathology,Characteristic Medical Center of The Chinese People's Armed Police Force,Tianjin 300162,China [3]Department of Respiratory Medicine,Sir Run Run Shaw Hospital and Institute of Translational Medicine,Zhejiang University School of Medicine,Hangzhou,Zhejiang 310016,China [4]Department of Pathology,Medical School,Dalian University,Dalian,Liaoning 116622,China [5]School of Integrative Medicine,Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China [6]Department of Colorectal Surgery,Tianjin Union Medical Center,Nankai University,Tianjin 300121,China

出　　处：《Genes & Diseases》2024年第2期542-545,共4页基因与疾病（英文）

基　　金：supported by grants from National Nature Science Foundation of China(No.81973356,81902826 and 82273963);Natural Science Foundation of Tianjin(No.21JCZDJC00060 and 21JCYBJC00180);the Fundamental Research Funds for the Central Universities of Nankai University(No.ZB22010404,3206054,91923101,63213082,and 92122017).

摘　　要：The tumor heterogeneity results in different clinical characteristics of tumor patients,so precise therapy is a popular treatment strategy clinically.Microsatellite instability(MSI)is found in 10%-15%of colorectal cancer(CRC)patients and exhibits different clinical outcomes than microsatellite stable(MSS)patients.Surprisingly,MSI patients have a better prognosis than patients with stable microsatellites.Msl patients exhibit clinical features that are not responsive to chemotherapy,however,Msl patients showed excellent responses to immunotherapy.'Although the subtype classification of MSI is beneficial to the clinical treatment of CRC patients,the mechanism of MSl remains unclear.

关 键 词：IMMUNOTHERAPY COLORECTAL clinical 

分 类 号：R735.37[医药卫生—肿瘤]