Vault RNAs(vtRNAs):Rediscovered non-coding RNAs with diverse physiological and pathological activities  

作　　者：Mahsa Aghajani Mir 

机构地区：[1]Deputy of Research and Technology,Health Research Institute,Babol University of Medical Sciences,Babol 47176-4774,Iran

出　　处：《Genes & Diseases》2024年第2期772-787,共16页基因与疾病（英文）

摘　　要：The physicochemical characteristics of RNA admit non-coding RNAs to perform a different range of biological acts through various mechanisms and are involved in regulating a diversity of fundamental processes.Notably,some reports of pathological conditions have proved abnormal expression of many non-coding RNAs guides the ailment.Vault RNAs are a class of non-coding RNAs containing stem regions or loops with well-conserved sequence patterns that play a fundamental role in the function of vault particles through RNA-ligand,RNA–RNA,or RNA-protein interactions.Taken together,vault RNAs have been proposed to be involved in a variety of functions such as cell proliferation,nucleocytoplasmic transport,intracellular detoxification processes,multidrug resistance,apoptosis,and autophagy,and serve as microRNA precursors and signaling pathways.Despite decades of investigations devoted,the biological function of the vault particle or the vault RNAs is not yet completely cleared.In this review,the current scientific assertions of the vital vault RNAs functions were discussed.

关 键 词：NCRNA Vault complex Vault RNA vtRNA viral infection TUMORIGENESIS 

分 类 号：R363[医药卫生—病理学]