Gp130-dependent STAT3 activation in M-CSF-derived macrophages exaggerates tumor progression  

作　　者：Yuting Xu Xiaoyu Xu Qianyue Zhang Peizhe Lu Chongjun Xiang Lei Zhang Chunhua Lin Qiaoling Song 

机构地区：[1]Key Laboratory of Marine Drugs,Ministry of Education of China,School of Medicine and Pharmacy,Ocean University of China,Qingdao,Shandong 266003,China [2]College of Marine Life Sciences,Ocean University of China,Qingdao,Shandong 266071,China [3]Department of Neuroscience,University of Michigan,Ann Arbor,M/48103,USA [4]Department of Urology,The Affiliated Yantai Yuhuangding Hospital of Qingdao University,Yantai,Shandong 264000,China [5]Research Center of Traditional Chinese Medicine and Clinical Pharmacy,Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University,Jinan,Shandong 250014,China [6]Innovation Platform of Marine Drug Screening&Evaluation,Qingdao National Laboratory for Marine Science and Technology,Qingdao,Shandong 266100,China

出　　处：《Genes & Diseases》2024年第3期51-54,共4页基因与疾病（英文）

基　　金：supported by the Shandong Province Major Scientific and Technological Innovation Project(China)(No.2020CXGC010503);the Shandong Provincial Key Laboratory Platform Project(China)(No.2021ZDSYS11);the National Natural Science Foundation of China Major Project(No.81991525).

摘　　要：Interleukin-6(IL-6)is a common pluripotent cytokine that is highly expressed in the tumor microenvironment.The IL-6/JAK/STAT3 signaling directly promotes tumor progression,severely hampering antitumor immunity.Macrophages,the richest innate immune cells within the tumor microenvironment,manipulate tumor progression via phenotypic plasticity.

关 键 词：STAT3 TUMOR INTERLEUKIN 

分 类 号：R73[医药卫生—肿瘤]