A novel mouse model of PEDF-associated serious liver inflammation,hepatic tumorigenesis and cardiovascular injury mimics human nonalcoholic steatohepatitis  

作　　者：Xinghui Li Haiping Wang Yandi Wu Li Zou Shijie Dengg Xintu Fu Tongsheng Huang Conghui Shen Teng Wu Weibin Cai 

机构地区：[1]Guangdong Engineering&Technology Research Center for Disease-Model Animals,Laboratory Animal Center,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong 510080,China [2]Department of Biochemistry,Zhongshan School of Medicine,Sun Yat-sen University,Guangzhou,Guangdong 510080,China [3]School of Pharmacy,Guangdong Pharmaceutical University,Guangzhou,Guangdong 510006,China [4]Guangdong Provincial Key Laboratory of Digestive Cancer Research,The Seventh Affiliated Hospital of Sun Yat-sen University,Shenzhen,Guangdong 518107,China

出　　处：《Genes & Diseases》2024年第1期11-14,共4页基因与疾病（英文）

基　　金：funded by the National Key Research and Development Program of China(No.2019YFA0801403);the National Natural Science Foundation of China(No.81670256,81970219,82170261,82000250,81741117);Guangdong Basic and Applied Basic Research Foundation(China)(No.2021A1515011005,2021B1212040006);China Postdoctoral Science Foundation(No.2020M672976);the Fundamental Research Funds for the Central University,Sun Yat-sen University,China(No.22qntd4808).

摘　　要：There are no approvedtherapeuticdrugs for nonalcoholic steatohepatitis(NASH)due to the many bottlenecks,including the lack of preclinical animal models that can perfectly mimic human NASH features,such as systemic metabolic disorders,hepatic steatosis,intense liver inflammation and fibrosis,liver tumorigenesis,and cardiovascularcomplications.i,2"Pigment"epitheliumderived factor(PEDF)is a lipid metabolism regulator with high expression in the liver,and its reduced expression in the liver is closely related to the development of nonalcoholic fatty liver disease(NAFLD).

关 键 词：INFLAMMATION PEDF HEPATIC 

分 类 号：R575[医药卫生—消化系统]