Distinct clinical profiles and mutation landscapes of gliomas originating from the neocortex,mesocortex,and cerebellum  

作　　者：Ye Cheng Lei Zhang Xiaolong Wu Hiroaki Wakimoto Haoming Geng Yukui Wei Geng Xu Xinru Xiao Jie Bai Yaming Wang Zeliang Hu Leiming Wang Qingtang Lian 

机构地区：[1]Department of Neurosurgery,Xuanwu Hospital,Capital Medical University,Beijing 100053,China [2]Brain Tumor Research Center,Massachusetts General Hospital,Department of Neurosurgery,Harvard Medical School,Boston,MA02134,USA [3]Department of Pathology,Xuanwu Hospital,Capital Medical University,Beijing 100053,China

出　　处：《Genes & Diseases》2024年第1期53-56,共4页基因与疾病（英文）

基　　金：funded by the Youth Program of the National Natural Science Foundation of China(No.81802485 to Y.Cheng);the Beijing New-star Plan of Science and Technology(China)(No.Z201100006820148 to Y.Cheng,No.Z201100006820149 to L.M.Wang).

摘　　要：Gliomas originating from anatomically and developmentally distinct brain regions have different clinical outcomes.However,the molecular landscape underlying this difference remains largelyunknown.We analyzed key molecular mutations via sequencing and correlated them with clinical characteristics in 180 adult patients with gliomas originating from the neocortex,mesocortex,and cerebellum.Cases of cerebellar origin had significantly longer survival than those of supratentorial origin,consistent with higher rates of mutation in key genes associated with supratentorial gliomas.

关 键 词：clinical CORTEX GLIOMA 

分 类 号：R739.41[医药卫生—肿瘤]