DNA damage chemotherapeutic drugs suppress basal-like breast cancer growth by down-regulating the transcription of the FOXO1-KLF5 axis  

作　　者：Qiuxia Cui Jian Sun Jingping Yuan Juanjuan Li Chuanyu Yang Guangshi Du Chengang Zhou Pu Qiu Jidong Gao Yuanqi Zhang Dewei Jiang Ceshi Chen 

机构地区：[1]Affiliated Hospital of Guangdong Medical University Science&Technology of China,Zhanjiang,Guangdong 524000,China [2]Department of Breast Surgical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Shenzhen,Guangdong 518116,China [3]Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province,Kunming Institute of Zoology,Chinese Academy of Sciences,Kunming,Yunnan 650223,China [4]Department of Pathology,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China [5]Department of Breast and Thyroid Surgery,Renmin Hospital of Wuhan University,Wuhan,Hubei 430060,China [6]Translational Medicine Research Center of Guizhou Medical University,Guiyang,Guizhou 550025,China [7]Department of Breast Surgical Oncology,National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100021,China [8]Yunnan Cancer Hospital and the Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer Center,Kunming,Yunnan 650500,China [9]Academy of Biomedical Engineering,Kunming Medical University,Kunming,Yunnan 650500,China

出　　处：《Genes & Diseases》2024年第1期91-94,共4页基因与疾病（英文）

基　　金：supported by the National Key R&D Program of China(No.2020YFA0112300);the National Natural Science Foundation of China(No.81830087,U2102203,82173014,81872414);the Yunnan Fundamental Research Projects(China)(No.202101AS070050,202001AW070018);major projects for fundamental research of Yunnan Province,China(No.202201BC070002);CAS"Light of West China"”Young Scholar Program,and Yunnan Revitalization Talent Support Program(China)(Yunling Shcolar Project and Young Talent Project);the Guangdong Foundation Committee for Basic and Applied Basic Research projects(China)(No.2022A1515012420);the Guangdong Medical University Affiliated Hospital Competitive Clinical Study(China)(No.LCYJ2021B003);the Guangdong Province Characteristic Innovation Projects(China)(No.2021KTSCX037).

摘　　要：Most basal-like breast cancers(BLBCs)have a poor prognosis and high crossover with triple-negative breast cancers(TNBCs).However,approximately 50%of TNBC patients develop chemoresistance.^(1) Dexamethasone reportedly induces Krüppel-like factor 5(KLF5)and can cause docetaxel and cisplatin resistance in TNBC.A super-enhancer can maintain the transcription of KLF5.

关 键 词：FOXO1 DRUGS damage 

分 类 号：R737.9[医药卫生—肿瘤]