Ribonucleotide reductase M2 (RRM2): Regulation, function and targeting strategy in human cancer  

作　　者：Zanwen Zuo Zerong Zhou Yuzhou Chang Yan Liu Yuping Shen Qizhang Li Lei Zhang 

机构地区：[1]Innovative Drug R&D Center,College of Life Sciences,Huaibei Normal University,Huaibei,Anhui 235000,China [2]National"111"Center for Cellular Regulation and Molecular Pharmaceutics,Key Laboratory of Fermentation Engineering(Ministry of Education),Hubei Key Laboratory of Industrial Microbiology,Cooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province),and School of Food and Biological Engineering,Hubei University of Technology,Wuhan,Hubei 430068,China [3]Department of Biomedical Informatics,The Ohio State University,Columbus,OH 43210,USA [4]School of Agriculture and Biology,and Engineering Research Center of Cell&Therapeutic Antibody,Ministry of Education,Shanghai Jiao Tong University,Shanghai 200240,China [5]College of Chemistry and Bioengineering,Hunan University of Science and Engineering,Yongzhou,Hunan425199,China [6]Department of Pharmaceutical Botany,School of Pharmacy,Naval Medical University,Shanghai 200433,China

出　　处：《Genes & Diseases》2024年第1期218-233,共16页基因与疾病（英文）

基　　金：supported by the Guiding Project of Science and Technology Research Program of the Hubei Provincial Department of Education(China)(No.B2020048);the Collaborative Grant-in-Aid of the HBUT National"111"CenterforCellular RegulationandMolecularPharmaceutics(China)(No.XBTK-2021006);the Open Project Funding of the Key Laboratory of Fermentation Engineering(Ministry of Education,China)(No.202105FE02);the Hubei University of Technology(China)(No.BSQD2020038).

摘　　要：Ribonucleotide reductase M2(RRM2)is a small subunit in ribonucleotide reduc-tases,which participate in nucleotide metabolism and catalyze the conversion of nucleotides to deoxynucleotides,maintaining the dNTP pools for DNA biosynthesis,repair,and replication.RRM2 performs a critical role in the malignant biological behaviors of cancers.The structure,regulation,and function of RRM2 and its inhibitors were discussed.RRM2 gene can produce two transcripts encoding the same ORF.RRM2 expression is regulated at multiple levels during the processes from transcription to translation.Moreover,this gene is associated with resistance,regulated cell death,and tumor immunity.In order to develop and design inhibitors of RRM2,appropriate strategies can be adopted based on different mechanisms.Thus,a greater appreciation of the characteristics of RRM2 is a benefit for understanding tumorigenesis,resistance in cancer,and tumor microenvironment.Moreover,RRM2-targeted therapy will be more attention in future therapeutic approaches for enhancement of treatment effects and amelioration of the dismal prognosis.

关 键 词：FUNCTION INHIBITION REGULATION Resistance RRM2 

分 类 号：Q522[生物学—生物化学] R73[医药卫生—肿瘤]