PD-L1-driven efficient enrichment and elimination of circulating cancer cells by magnetic MoSe_(2) nanosheet  

作　　者：Hongjie Huang Binhua Zou Shanlin Zhu Xingchen Zhang Jiale Huang Jinlin Wang Xiaoling Li Tianfeng Chen 

机构地区：[1]The Sixth Affiliated Hospital,Jinan University,Dongguan 523566,China [2]Department of Chemistry,Institute of Food Safety and Nutrition,Jinan University,Guangzhou 510632,China [3]Department of Rehabilitation Medicine,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China [4]Pulmonary and Critical Care Medicine,Guangzhou Institute of Respiratory Health,National Clinical Research Center for Respiratory Disease,National Center for Respiratory Medicine,State Key Laboratory of Respiratory Diseases,The First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China

出　　处：《Nano Research》2024年第5期4350-4358,共9页纳米研究（英文版）

基　　金：supported by the National Natural Science Fund for Distinguished Young Scholars(No.82225025);the National Natural Science Foundation of China(Nos.21877049,32171296);China Postdoctoral Science Foundation(No.2021M690066);Guangdong Basic and Applied Basic Research Foundation(No.2021A1515110300).

摘　　要：Circulating tumor cells(CTCs)are important biomarkers in the development and progression of lung cancer because they can reach other organs through the blood circulation and form distant metastases,exacerbating lung cancer progression.The presence of CTCs is also the main reason for the failure of nanomedicine-based lung cancer treatments.Therefore,magnetic MoSe_(2) nanosheets loaded with programmed death-ligand 1(PD-L1),named PD-L1-MFP NS,were employed here to precisely capture lung cancer CTCs in the blood circulation through the tumor-targeting effect of PD-L1 killing CTCs with highly effective photothermal therapy(PTT).In addition,by increasing the expression of cytomegalovirus UL16-binding protein(ULBP)ligands on tumor cells,the PD-L1-MFP NS further activated natural killer(NK)cells and triggered NK cell-induced cancer immunotherapy,thereby enhancing the overall tumor-killing effect.In summary,this material designed to capture CTCs provides a substantial advancement for personalized PTT-triggered immunotherapy and has great clinical translational potential.

关 键 词：circulating tumor cells SELENIDE photothermal therapy(PTT) natural killer(NK)cell IMMUNOTHERAPY 

分 类 号：R730[医药卫生—肿瘤]