Design consideration of phthalocyanines as sensitizers for enhanced sono-photodynamic combinatorial therapy of cancer  

作　　者：Lindokuhle Cindy Nene Heidi Abrahamse 

机构地区：[1]Laser Research Centre,Faculty of Health Sciences,University of Johannesburg,Doornfontein 2028,South Africa

出　　处：《Acta Pharmaceutica Sinica B》2024年第3期1077-1097,共21页药学学报（英文版）

基　　金：supported by the National Research Foundation of South Africa;based on the research supported by the South African Research Chairs Initiative of the Department of Science and Technology and National Research Foundation of South Africa(Grant No.98337);the University of Johannesburg;the National Laser Centre;the National Research Foundation-South African Research Chairs Initiative(NRF-SARChI)for their financial grant support。

摘　　要：Cancer remains one of the diseases with the highest incidence and mortality globally.Conventional treatment modalities have demonstrated threatening drawbacks including invasiveness,noncontrollability,and development of resistance for some,including chemotherapy,radiation,and surgery.Sono-photodynamic combinatorial therapy(SPDT)has been developed as an alternative treatment modality which offers a non-invasive and controllable therapeutic approach.SPDT combines the mechanism of action of sonodynamic therapy(SDT),which uses ultrasound,and photodynamic therapy(PDT),which uses light,to activate a sensitizer and initiate cancer eradication.The use of phthalocyanines(Pcs)as sensitizers for SPDT is gaining interest owing to their ability to induce intracellular oxidative stress and initiate toxicity under SDT and PDT.This review discusses some of the structural prerequisites of Pcs which may influence their overall SPDT activities in cancer therapy.

关 键 词：Sonodynamic therapy Photodynamic therapy Combinatorial therapy Phthalocyanines SENSITIZER CANCER 

分 类 号：R730.5[医药卫生—肿瘤] TQ421.7[医药卫生—临床医学]