Ergothioneine and its congeners:anti-ageing mechanisms and pharmacophore  

作　　者：Li Chen Liping Zhang Xujun Ye Zixin Deng Changming Zhao 

机构地区：[1]Department of Geriatrics,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan 430072,China [2]Key Laboratory of Combinatory Biosynthesis and Drug Discovery,School of Pharmaceutical Sciences,Ministry of Education,Wuhan University,Wuhan 430072,China tThese authors contributed equally.

出　　处：《Protein & Cell》2024年第3期191-206,共16页蛋白质与细胞（英文版）

基　　金：supported by grants from the National Key R&D Program of China(No.2018YFA0903200 to C.Z.);the National Natural Science Foundation of China(Nos.32270032 and 32070038 to C.Z.,No.32000029 to L.C.).

摘　　要：Ergothioneine,Ovothiol,and Selenoneine are sulfur/selenium-containing histidine-derived natural products widely distributed across different organisms.They exhibit significant antioxidant properties,making them as potential lead compounds for promoting health.Increasing evidence suggests that Ergothioneine is positively correlated with healthy ageing and longevity.The mechanisms underlying Ergothioneine's regulation of the ageing process at cellular and molecular levels are beginning to be understood.In this review,we provide an in-depth and extensive coverage of the anti-ageing studies on Ergothioneine and discuss its possible intracellular targeting pathways.In addition,we highlight the recent efforts in elucidating the biosynthetic details for Ergothioneine,Ovothiol,and Selenoneine,with a particular focus on the study of their pharmacophore-forming enzymology.

关 键 词：ERGOTHIONEINE antioxidant ANTI-AGEING LONGEVITY biosynthesis ENZYMOLOGY 

分 类 号：R97[医药卫生—药品]