南极磷虾油的营养特性及其改善骨质疏松症的研究进展  

Research progress on nutritional properties of Antarctic krill oil and its improvement on osteoporosis

作　　者：胡子聪 杨可君 房翠兰[5] HU Zicong;YANG Kejun;FANG Cuilan(Southern Zhejiang Key Laboratory of Crop Breeding,Wenzhou Academy of Agricultural Science,Wenzhou 325006,Zhejiang,China;College of Food Science,Southwest University,Chongqing 400715,China;Institute of Food Science,Wenzhou Academy of Agricultural Science,Wenzhou 325006,Zhejiang,China;Orthopedic Hospital Affiliated to Wenzhou Medical University,Wenzhou 325027,Zhejiang,China;Centre for Disease Control and Prevention of Jiulongpo,Chongqing 400039,China)

机构地区：[1]温州市农业科学研究院浙南作物育种重点实验室,浙江温州325006 [2]西南大学食品科学学院,重庆400715 [3]温州市农业科学研究院食品科学研究所,浙江温州325006 [4]温州医科大学附属骨科医院,浙江温州325027 [5]重庆市九龙坡区疾病预防控制中心,重庆400039

出　　处：《中国油脂》2024年第4期32-39,共8页China Oils and Fats

基　　金：重庆市首批公共卫生重点学科(理化与卫生毒理)建设项目。

摘　　要：南极磷虾油(AKO)是一种新型的海洋功能性油脂。为了促进AKO的临床应用,在综述AKO营养组成的基础上,对AKO改善骨质疏松症的作用机制进行了阐述,并对未来的重点工作进行了展望。AKO富含磷脂、n-3型多不饱和脂肪酸(n-3 PUFA)、虾青素、α-生育酚等多种活性因子。AKO改善骨质疏松症的作用机制有3种,即抑制破骨细胞产生、促进骨细胞形成和调控骨髓间充质干细胞。在AKO未来的深入研究中,应聚焦于大规模临床研究、标准剂量和长期效果验证等方面。Antarctic krill oil(AKO)is a novel marine functional lipid.In order to promote the clinical application of AKO,the nutritional composition of AKO was summarized,the mechanism of AKO in improving osteoporosis was described,and the future key work was prospected.AKO is rich in phospholipids,n-3 polyunsaturated fatty acids(n-3 PUFA),astaxanthin,α-tocopherol,and other bioactive factors.There are three mechanisms for AKO to improve osteoporosis,namely,inhibiting osteoclastogenesis,promoting osteoblastogenesis,and regulating bone marrow mesenchymal stem cells.Future in-depth investigations into AKO should focus on large-scale clinical trials,standardized dosages,and long-term efficacy validation.

关 键 词：南极磷虾油 脂质 脂质伴随物 n-3型多不饱和脂肪酸 骨质疏松症 

分 类 号：TS225.2[轻工技术与工程—粮食、油脂及植物蛋白工程] R151[轻工技术与工程—食品科学与工程]