卵巢储备功能减退遗传学研究进展  

A review of ovarian genes associated with diminished ova-rian reserve

作　　者：张明 秦雪 祝钦滢 梁晓磊[2] Zhang Ming;Qin Xue;Zhu Qinying;Liang Xiaolei(Department of Rehabilitation,The First Hospital of Lanzhou University,Lanzhou 730000,China;Department of Obstetrics and Gynecology,The First Hospital of Lanzhou University,Lanzhou 730000,China;The First Clinical Medical School,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一医院康复科,甘肃兰州730000 [2]兰州大学第一医院妇产科,甘肃兰州730000 [3]兰州大学第一临床医学院,甘肃兰州730000

出　　处：《兰州大学学报（医学版）》2024年第2期73-79,共7页Journal of Lanzhou University（Medical Sciences）

基　　金：国家自然科学基金地区基金资助项目(81960278);甘肃省自然科学基金资助项目(22JR5RA934);兰州大学第一医院院内基金资助项目(ZX-62000002-2021-335)。

摘　　要：卵巢储备功能减退(DOR)是卵巢早衰的早中期阶段,会对女性的生育能力产生不良影响,导致育龄期女性生育能力下降,其病因复杂、多样,遗传因素在DOR的发生发展中发挥重要作用。随着全外显子和基因组测序技术的快速发展,一些DOR致病相关基因,例如:胆固醇、激素合成及减数分裂过程中的多种基因的改变逐渐被揭示。Diminished ovarian reserve(DOR),as a common female endocrine disease,was considered to be an early to middle stage of premature ovarian failure,which would adversely affect female fertility and lead to a decrease in fertility in women of childbearing age.The etiology of DOR was complex and varied,with genetic factors being also one of the important factors.With the rapid development of whole exome and genome sequencing technology,the changes in some DOR pathogenic genes,such as cholesterol,hormone synthesis and meiosis,have been revealed one by one.

关 键 词：卵巢储备功能减退 遗传学 胆固醇 激素合成 有丝分裂 

分 类 号：R711.2[医药卫生—妇产科学]