PGC-lα调控畜禽肌肉脂肪生长代谢及其与肉品质研究进展  

Progress in research on relationship between regulation of peroxisome proliferator-activated receptorγ-coactivator-1αon growth and metabolism of muscle and fat and meat quality in livestock and poultry

作　　者：辛建增 唐婷 刘盛 XIN Jianzeng;TANG Ting;LIU Sheng(College of Life Sciences,Yantai University,Yantai 264000,China;College of Pharmacy,Yantai University,Yantai 264000,China)

机构地区：[1]烟台大学生命科学学院,山东烟台264000 [2]烟台大学药学院,山东烟台264000

出　　处：《畜牧与兽医》2024年第5期138-145,共8页Animal Husbandry & Veterinary Medicine

基　　金：烟台大学博士启动基金项目(SM20B113)。

摘　　要：过氧化物酶体增殖物激活受体γ辅激活因子1α(PGC-lα)是一种具有广泛功能的转录调节因子,其在动物体内参与线粒体生物合成、肌纤维类型转化、脂肪分化、肌内脂肪沉积、糖脂代谢、能量代谢等多项生理过程,其中,肌纤维类型和肌内脂肪含量与肉品质密切相关。因此,在分子水平深入探究PGC-1α调控肌肉和脂肪的生长代谢过程将为改善肉品质提供新的研究思路。本文系统概述了PGC-lα的结构特点及PGC-1α调控肌肉线粒体增生、脂肪分化、能量代谢等过程的机制,重点介绍了PGC-lα调控肌纤维类型转化、肌内脂肪沉积、糖类代谢及其与肉品质形成之间的可能关系,以期为今后通过PGC-1α调控畜禽肌肉脂肪生长代谢,进而改善肉品质提供参考。Peroxisome proliferator-activated receptorγ(PPAR-γ)coactivator 1α(PGC-lα)is a versatile transcriptional regulator.This regulator is involved in many physiological processes such as mitochondrial biosynthesis,muscle fiber type transformation,adipose differenti-ation,intramuscular adipose deposition,glycolipid metabolism,and energy metabolism in animals.Muscle fiber type and intramuscular fat content are closely related to meat quality.Therefore,exploring the regulation of PGC-1αon the growth and metabolism of muscle and fat at the molecular level will provide new research ideas for improving meat quality.In this paper,the structural characteristics of PGC-lαand the mechanism of PGC-1αregulating muscle mitochondria,adipose differentiation and energy metabolism are systematically reviewed.The regu-lation of PGC-lαon muscle fiber type transformation,intramuscular fat deposition,carbohydrate metabolism and its possible relationship with the formation of meat quality are emphasized;which provides reference for improving meat quality by regulating the growth and metabo-lism of muscle and fat by PGC-1αin livestock and poultry.

关 键 词：过氧化物酶体增殖物激活受体γ辅激活因子1α 肌纤维类型 肌内脂肪沉积 能量代谢 肉品质 

分 类 号：S826[农业科学—畜牧学]