非酒精性脂肪性肝病进程中低氧的作用及其机制研究进展  

Research Progress on the Role and Mechanisms of Hypoxia in the Progression of Non-Alcoholic Fatty Liver Disease

作　　者：颜然然 沈利娟[5] 林凯歌 格日力[1,3] 白振忠[1,2,3] YAN Ran-Ran;SHEN Li-Juan;LIN Kai-Ge;GE Ri-Li;BAI Zhen-Zhong(Research Center for High Altitude Medicine,Qinghai University,Xining 810001,China;Key Laboratory of High-Altitude Medicine in Qinghai University,Ministry of Education,Xining 810001,China;Qinghai-Utah Joint Key Lab for High-altitude Medicine,Medical College of Qinghai University,Xining 810001,China;Department of Respiratory and Critical Care Medicine,Handan First Hospital,Handan 056000,China;Department of Gastroenterology,Affiliated Hospital of Qinghai University,Xining 810001,China)

机构地区：[1]青海大学高原医学研究中心,西宁810001 [2]青海大学高原医学教育部重点实验室,西宁810001 [3]青海大学医学院青海省高原医学应用基础重点实验室(青海-犹他高原医学联合重点实验室),西宁810001 [4]邯郸市第一医院呼吸与危重医学二科,邯郸056000 [5]青海大学附属医院消化内科,西宁810001

出　　处：《生理科学进展》2024年第2期171-178,共8页Progress in Physiological Sciences

基　　金：青海省科技计划项目(2020-ZJ-721);青海省“昆仑英才”创新人才项目(2022年)资助课题。

摘　　要：非酒精性脂肪性肝病(non-alcoholic fatty liver disease,NAFLD)是全国范围内普遍发病的慢性非传染性肝脏疾病,也是肝硬化肝癌的前期阶段,严重威胁着人类健康。高原低氧条件下机体各器官系统受到不同程度影响,而肝脏组织缺氧程度进一步加重,呈现出高原地区NAFLD的患病率显著高于平原地区。目前NAFLD发病机制观点不一,而且高原低氧促进NAFLD进展机制尚不明确。本文从高原低氧对肝实质细胞和间充质细胞的影响角度入手,整合、梳理相关研究报道,并探索高原低氧在NAFLD慢性病进展中发生、发展的可能机制,为NAFLD的预防、诊治提供新思路。Non-alcoholic fatty liver disease(NAFLD)is a prevalent chronic non-infectious liver disease nationwide that can progress to liver cirrhosis and liver cancer,posing a significant threat to human health.Under hypoxic conditions at high altitudes,various organs and systems of the body are affected.Liver tissues,in particular,experience intensified hypoxia,leading to a significantly higher prevalence of NAFLD in plateau areas than in sea level areas.Currently,there are diverse opinions on the pathogenesis of NAFLD,and the specific mechanisms by which high-altitude hypoxia promotes NAFLD progression remain unclear.In this article,we review the impact of high-altitude hypoxia on liver parenchymal cells and mesenchymal cells,consolidate relevant research findings,and summarize the potential mechanisms by which high-altitude hypoxia may contribute to the progression of chronic NAFLD,providing new insights for the prevention and treatment of NAFLD.

关 键 词：NAFLD 低氧 脂肪变性 炎症 纤维化进展 

分 类 号：R575.1[医药卫生—消化系统]