Age-related differences in long-term potentiation-like plasticity and shortlatency afferent inhibition and their association with cognitive function  

作　　者：Qian Lu Sisi Huang Tianjiao Zhang Jie Song Manyu Dong Yilun Qian Jing Teng Tong Wang Chuan He Ying Shen 

机构地区：[1]Department of Rehabilitation Medicine,The Affiliated Jiangsu Shengze Hospital of Nanjing Medical University,Suzhou,China [2]Rehabilitation Medicine Center,The First Affiliated Hospital of Nanjing Medical University,Nanjing,China

出　　处：《General Psychiatry》2024年第1期73-82,共10页综合精神医学（英文）

基　　金：the National Key Research and Development Program of China(2022YFC2009700);the National Science Foundation of China(82372582);the Medical Applications Basic Research Project of Suzhou Science and Technology Bureau(SKY2023033);the Wujiang District Science,Education,Health and Promotion Project(WWK202021).

摘　　要：Background The neurophysiological differences in cortical plasticity and cholinergic system function due to ageing and their correlation with cognitive function remain poorly understood.Aims To reveal the differences in long-term potentiation(LTP)-like plasticity and short-latency afferent inhibition(SAl)between older and younger individuals,alongside their correlation with cognitive function using transcranial magnetic stimulation(TMS).Methods The cross-sectional study involved 31 younger adults aged 18-30 and 46 older adults aged 60-80.All participants underwent comprehensive cognitive assessments and a neurophysiological evaluation based on TMS.Cognitive function assessments included evaluations of global cognitive function,language,memory and executive function.The neurophysiological assessment included LTP-like plasticity and SAl.Results The findings of this study revealed a decline in LTP among the older adults compared with the younger adults(wald χ^(2)=3.98,p=0.046).Subgroup analysis further demonstrated a significant reduction in SAl level among individuals aged 70-80 years in comparison to both the younger adults(SAI(N20)):(t=-3.37,p=0.018);SAl(N20+4):(t=-3.13,p=0.038)and those aged 60-70(SAl(N20)):(t=3.26,p=0.025);SAl(N20+4):(t=-3.69,p=0.006).Conversely,there was no notable difference in SAl level between those aged 60-70 years and the younger group.Furthermore,after employing the Bonferroni correction,the correlation analysis revealed that only the positive correlation between LTP-like plasticity and language function(r=0.61,p<0.001)in the younger group remained statistically significant.Conclusions During the normal ageing process,a decline in synaptic plasticity may precede cholinergic system dysfunction.In individuals over 60 years of age,there is a reduction in LTP-like plasticity,while a decline in cholinergic system function is observed in those over 70.Thus,the cholinergic system may play a vital role in preventing cognitive decline during normal ageing.In younger individuals,LTP-like plastici

关 键 词：function YOUNGER PLASTICITY 

分 类 号：R749[医药卫生—神经病学与精神病学]