Methodological considerations of priming repetitive transcranial magnetic stimulation protocols in clinical populations  

作　　者：Jack Jiaqi Zhang Zhongfei Bai Kenneth N K Fong 

机构地区：[1]Department of Rehabilitation Sciences,The Hong Kong Polytechnic University,Hong Kong,China [2]Shanghai YangZhi Rehabilitation Hospital(Shanghai Sunshine Rehabilitation Centre),School of Medicine,Tongji University,Shanghai,China

出　　处：《General Psychiatry》2024年第1期173-176,共4页综合精神医学（英文）

基　　金：the Shanghai Municipal Health Commission Clinical ResearchProgram(20224Y0220)to ZB;Start-up Fundfor RAPs under the Strategic Hiring Scheme(P0048866)and JJZ.

摘　　要：INTRODUCTION Repetitive transcranial magnetic stimulation(rTMS)is a neuroplasticity-enhancing technique that modifies brain responsiveness to various therapeutic modalities in clinical psychiatric and neurological applications. Furthermore,its effect can be attributed to long-term potentiation(LTP)or longterm depression(LTD)-like neuroplasticity.However,responsiveness to rTMS is largely variable in healthy and pathological brains and is mediated by complex biological mechanisms.Metaplasticity refers to a higher-order plasticity mechanism in which the direction and magnitude of synaptic plasticity are modified by prior neuronal activity and is believed to be a significant factor leading to the response variability of rTMs.

关 键 词：STIMULATION CLINICAL TRANSCRANIAL 

分 类 号：R749[医药卫生—神经病学与精神病学]