人类胚胎干细胞DNA损伤修复机制的研究进展  

Research progress on the repair mechanisms of DNA damage in human embryonic stem cells

作　　者：曾鹏 武晓茸 李敏瑶 张曼琴 田美 李永刚[1] Zeng Peng;Wu Xiaorong;Li Minyao;Zhang Manqin;Tian Mei;Li Yonggang(NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China Department of Reproductive Medicine,the First People's Hospital of Yunnan Province the Affiliated Hospital of Kunming University of Science and Technology,Kunming 650034,China)

机构地区：[1]国家卫生健康委西部优生与出生缺陷防控重点实验室、云南省第一人民医院生殖医学科、昆明理工大学附属医院,昆明650034

出　　处：《中华生殖与避孕杂志》2024年第3期331-336,共6页Chinese Journal of Reproduction and Contraception

基　　金：昆医联合项目(202001AY070001-296);云南省生殖妇产疾病临床医学中心开放课题(zx2019-01-01:2020LCZXKF-SZ13,2021LCZXXF-SZ10)。

摘　　要：胚胎干细胞具有显著的增殖和分化发育能力,因此在细胞治疗、疾病建模和药物研发方面具有巨大的潜力。但高效的全能性却导致其往往伴随基因组的不稳定性,尤其在DNA损伤方面更加凸显。人类胚胎干细胞拥有特殊的修复机制,用以避免这类损伤在细胞内的积累或向子代的传递,进而保障自我复制和分化发育的准确性和安全性。本文对人类胚胎干细胞DNA损伤的修复机制进行了总结,旨在为结合其修复机制,进一步探索干细胞治疗的新思路提供依据。Embryonic stem cells have remarkable proliferative and differentiation developmental capabilities and thus have great potential for cell therapy,disease modeling,and drug development.However,such totipotency has resulted in genomic instability,especially in the case of DNA damage.Human embryonic stem cells possess particular repair mechanisms to avoid the accumulation of such damage within the cell or its transmission to the offspring,thus ensuring the accuracy and safety of self-replication and differentiation development.This paper summarized the repair mechanisms of DNA damage in human embryonic stem cells and intends to provide a basis for further exploration of new ideas of stem cell therapy in conjunction with their repair mechanisms.

关 键 词：基因组不稳定性 人类胚胎干细胞 DNA修复机制 干细胞治疗 

分 类 号：R394[医药卫生—医学遗传学]