葛渣膳食纤维对小鼠胃肠蠕动促进作用研究  

Effect of Dietary Fiber from Pueraria Lobata Residue on Gastrointestinal Peristalsis in Mice

作　　者：游剑[1,2] 张洁 李梦楚[1,2] 吴东 龚建平 YOU Jian;ZHANG Jie;LI Mengchu;WU Dong;GONG Jianping(Jiangxi University of Chinese Medicine,Nanchang 330006,China;Jiangxi Herbfine Hi-tech Co.,Ltd.,Nanchang 330006,China.)

机构地区：[1]江西中医药大学,南昌330006 [2]江西本草天工科技有限责任公司,南昌330006

出　　处：《江西中医药大学学报》2024年第2期94-96,106,共4页Journal of Jiangxi University of Chinese Medicine

基　　金：国家重点研发计划项目(2017YFC1702906)。

摘　　要：目的:检验葛渣中水不溶性膳食纤维是否具有促进肠胃蠕动的作用,并检测不同浓度的葛渣膳食纤维对肠胃蠕动促进效果的差异。方法:建立小肠正常蠕动的抑制模型(便秘模型),然后采用小肠运动实验和小鼠排便实验2个实验检测葛渣的水不溶性膳食纤维是否具有促进胃肠蠕动的作用,从而判断葛渣膳食纤维是否具有润肠通便的效果。结果:与模型对照组比较,小肠运动实验中高、中、低剂量组的小肠墨汁推进长度和推进率均有显著性差异,小鼠排便实验的高、中、低剂量组小鼠在首便时间、6 h粪便粒数和6 h粪便总量均有显著性差异(P<0.05)。结论:葛渣水不溶性膳食纤维具有润肠通便的作用。Objective:To test whether the insoluble dietary fiber in Pueraria lobata residue can promote gastrointestinal peristalsis,and to test the difference of promoting effect of different concentrations of Pueraria lobata residue dietary fiber on gastrointestinal peristalsis.Methods:It had established a normal intestinal peristalsis inhibition model(constipation model),and then used intestinal movement test and mouse defecation test to detect whether the water-insoluble dietary fiber of Pueraria lobata residue has the effect of promoting gastrointestinal peristalsis,so as to judge whether the dietary fiber of Pueraria lobata residue has the effect of moistening intestines and defecating.Results:Compared with the model control group,in the small intestine movement experiment,there were significant differences in the small intestine ink advancing length and advancing rate among the high,medium and low dose groups.In the defecation experiment of mice,the high,medium and low dose groups had significant differences in the first stool time,the number of feces particles and the total amount of feces in 6 h(P<0.05).Conclusion:Water-insoluble dietary fiber from Pueraria lobata residue has the effect of moistening intestines and relieving constipation.

关 键 词：葛渣 膳食纤维 小肠运动实验 通便实验 

分 类 号：R285[医药卫生—中药学]