Sepsis during short bowel syndrome hospitalizations:Identifying trends,disparities,and clinical outcomes in the United States  

作　　者：Dushyant Singh Dahiya Jennifer Wachala Shantanu Solanki Dhanshree Solanki Asim Kichloo Samantha Holcomb Uvesh Mansuri Khwaja Saad Haq Hassam Ali Manesh Kumar Gangwani Yash R Shah Teresa Varghese Hafiz Muzaffar Akbar Khan Simon Peter Horslen Thomas D Schiano Syed-Mohammed Jafri 

机构地区：[1]Division of Gastroenterology,Hepatology&Motility,The University of Kansas School of Medicine,Kansas City,KS 66160,United States [2]Department of Internal Medicine,Samaritan Medical Center,Watertown,NY 13601,United States [3]Division of Gastroenterology Hepatology&Nutrition,The University of Texas MD Anderson Cancer Center,Houston,TX 77030,United States [4]Department of Medicine,Institute for Foreign Medical Graduate Education,Houston,TX 77030,United States [5]Department of Internal Medicine,MedStar Harbor Hospital,Baltimore,MD 21225,United States [6]Department of Internal Medicine,WellStar Spalding Regional Hospital,Griffin,GA 30224,United States [7]Division of Gastroenterology,Hepatology and Nutrition,East Carolina University/Brody School of Medicine,Greenville,NC 27858,United States [8]Department of Gastroenterology and Hepatology,University of Arkansas for Medical Sciences,Little Rock,AR 72205,United States [9]Department of Internal Medicine,Trinity Health Oakland/Wayne State University,Pontiac,MI 48341,United States [10]Division of Gastroenterology and Hepatology,SUNY Upstate Medical University,Syracuse,NY 13210,United States [11]Department of Pediatrics,School of Medicine and UPMC Children’s Hospital of Pittsburgh,University of Pittsburgh,Pittsburgh,PA 15219,United States [12]Division of Liver Diseases,Icahn School of Medicine at Mount Sinai,New York,NY 10029,United States [13]Division of Gastroenterology and Hepatology,Henry Ford Hospital,Detroit,MI 48202,United States

出　　处：《World Journal of Gastrointestinal Pathophysiology》2024年第1期26-36,共11页世界胃肠病理生理学杂志（英文版）（电子版）

摘　　要：BACKGROUND Short bowel syndrome(SBS)hospitalizations are often complicated with sepsis.There is a significant paucity of data on adult SBS hospitalizations in the United States and across the globe.AIM To assess trends and outcomes of SBS hospitalizations complicated by sepsis in the United States.METHODS The National Inpatient Sample was utilized to identify all adult SBS hospitalizations between 2005-2014.The study cohort was further divided based on the presence or absence of sepsis.Trends were identified,and hospitalization characteristics and clinical outcomes were compared.Predictors of mortality for SBS hospitalizations complicated with sepsis were assessed.RESULTS Of 247097 SBS hospitalizations,21.7%were complicated by sepsis.Septic SBS hospitalizations had a rising trend of hospitalizations from 20.8%in 2005 to 23.5%in 2014(P trend<0.0001).Compared to non-septic SBS hospitalizations,septic SBS hospitalizations had a higher proportion of males(32.8%vs 29.3%,P<0.0001),patients in the 35-49(45.9%vs 42.5%,P<0.0001)and 50-64(32.1%vs 31.1%,P<0.0001)age groups,and ethnic minorities,i.e.,Blacks(12.4%vs 11.3%,P<0.0001)and Hispanics(6.7%vs 5.5%,P<0.0001).Furthermore,septic SBS hospitalizations had a higher proportion of patients with intestinal transplantation(0.33%vs 0.22%,P<0.0001),inpatient mortality(8.5%vs 1.4%,P<0.0001),and mean length of stay(16.1 d vs 7.7 d,P<0.0001)compared to the non-sepsis cohort.A younger age,female gender,White race,and presence of comorbidities such as anemia and depression were identified to be independent predictors of inpatient mortality for septic SBS hospitalizations.CONCLUSION Septic SBS hospitalizations had a rising trend between 2005-2014 and were associated with higher inpatient mortality compared to non-septic SBS hospitalizations.

关 键 词：Short bowel syndrome SEPSIS Outcomes MORTALITY TRENDS 

分 类 号：R574.62[医药卫生—消化系统]