Understanding the role of transmembrane 9 superfamily member 1 in bladder cancer pathogenesis  

作　　者：Venkata Krishna Vamsi Gade Budhi Singh Yadav 

机构地区：[1]Department of Radiotherapy&Oncology,Postgraduate Institute of Medical Education and Research,Chandigarh 160012,India [2]Department of Radiotherapy&Oncology,Regional Cancer Centre,Postgraduate Institute of Medical Education and Research,Chandigarh 160012,India

出　　处：《World Journal of Clinical Oncology》2024年第4期468-471,共4页世界临床肿瘤学杂志（英文版）

摘　　要：In this editorial we comment on the article by Wei et al,published in the recent issue of the World Journal of Clinical Oncology.The authors investigated the role of Transmembrane 9 superfamily member 1(TM9SF1)protein in bladder cancer(BC)carcinogenesis.Lentiviral vectors were used to achieve silencing or overexpression of TM9SF1 gene in three BC cell lines.These cell lines were then subject to cell counting kit 8,wound-healing assay,transwell assay,and flow cytometry.Proliferation,migration,and invasion of BC cells were increased in cell lines subjected to TM9SF1 overexpression.TM9SF1 silencing inhibited proliferation,migration and invasion of BC cells.The authors conclude that TM9SF1 may be an oncogene in bladder cancer pathogenesis.

关 键 词：Urinary bladder cancer Transmembrane 9 superfamily member 1 gene cell line Lentiviral vectors Wound healing assay ONCOGENE Proliferation Migration 

分 类 号：R735[医药卫生—肿瘤]