Britanin–a beacon of hope against gastrointestinal tumors?  

作　　者：Agnieszka Kajdanek Damian Kołat Lin-Yong Zhao Mateusz Kciuk Zbigniew Pasieka Żaneta Kałuzińska-Kołat 

机构地区：[1]Department of Biomedicine and Experimental Surgery,Medical University of Lodz,Lodz 90-136,Lodzkie,Poland [2]Department of Functional Genomics,Medical University of Lodz,Lodz 90-752,Lodzkie,Poland [3]Department of General Surgery&Laboratory of Gastric Cancer,State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [4]Gastric Cancer Center,West China Hospital,Sichuan University,Chengdu 610041,Sichuan Province,China [5]Department of Molecular Biotechnology and Genetics,University of Lodz,Lodz 90-237,Lodzkie,Poland

出　　处：《World Journal of Clinical Oncology》2024年第4期523-530,共8页世界临床肿瘤学杂志（英文版）

摘　　要：Britanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant properties.It also exhibits significant anti-tumor activity,suppressing tumor growth in vitro and in vivo.The current body of research on Britanin includes thirty papers predominantly related to neoplasms,the majority of which are gastrointestinal tumors that have not been summarized before.To drive academic debate,the present paper reviews the available research on Britanin in gastrointestinal tumors.It also outlines novel research directions using data not directly concerned with the digestive system,but which could be adopted in future gastrointestinal research.Britanin was found to counteract liver,colorectal,pancreatic,and gastric tumors,by regulating proliferation,apoptosis,autophagy,immune response,migration,and angiogenesis.As confirmed in pancreatic,gastric,and liver cancer,its most commonly noted molecular effects include nuclear factor kappa B and B-cell lymphoma 2 downregulation,as well as Bcl-2-associated X protein upregulation.Moreover,it has been found to induce the Akt kinase and Forkhead box O1 axis,activate the AMP-activated protein kinase pathway,elevate interleukin-2 and peroxisome proliferator-activated receptor-γlevels,reduce interleukin-10,as well as downregulate matrix metalloproteinase-9,Twist family bHLH transcription factor 1,and cyclooxygenase-2.It also inhibits Myc–HIF1αinteraction and programmed death ligand 1 transcription by interrupting the Ras/RAF/MEK/ERK pathway and mTOR/P70S6K/4EBP1 signaling.Future research should aim to unravel the link between Britanin and acetylcholinesterase,mast cells,osteolysis,and ischemia,as compelling data have been provided by studies outside the gastrointestinal context.Since the cytotoxicity of Britanin on noncancerous cells is significantly lower than that on tumor cells,while still being effective against the latter,further in-depth studies with the use of animal models are merited.The compound exhibits pleiotropic biological activity and off

关 键 词：Britanin Sesquiterpene lactones CHEMOTHERAPEUTICS Gastrointestinal tumors In vitro In vivo 

分 类 号：R735[医药卫生—肿瘤]