financially supported by the National Natural Science Foundation of China(Projects 52173147,52203202,51973218);the Scientific and Technological Development Projects of Jilin Province(20240202002GX).
Due to the immunosuppressive tumor microenvironment(TME),T cells are usually inactivated and tend to differentiate into regulatory T cells(Tregs)in the tumor tissues,which seriously hinders the anti-tumor efficiency o...
This work was financially supported by the National Key R&D Program of China(Nos.2022YFA1205703 and 2022YFA1205702);the National Natural Science Foundation of China(Nos.51773099,51933006 and 52103183);Haihe Laboratory of Sustainable Chemical Transformations(No.YYJC202102).
Efficient intracellular delivery of protein drugs is critical for protein therapy.The combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer effect.However,co-deli...
Britanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant properties.It also exhibits significant anti-tumor activity,suppressing tumor growth in vitro and in vivo.The curre...
Supported by Zhejiang Province Traditional Chinese Medicine Science and Technology Project,No.2024ZL1296.
BACKGROUND Monomorphic epithelial intestinal T-cell lymphoma(MEITL)is a rare type of peripheral T-cell lymphoma.The clinical manifestations are diarrhea,abdominal pain,perforation and an abdominal mass.CASE SUMMARY We...
BACKGROUND Rhabdomyosarcoma is a tumor of mesenchymal origin.Secondary leukemia is a complication of previous transformation to other hematologic disorders or is a treatment-related acute myeloid leukemia secondary to...
This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(22002018);the Innovative Research Team of High-level Local University in Shanghai,and the Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning.
Drug therapy is among the most widely used methods in disease treatment.However,there remains a trade-off problem between drug dosage and toxicity.Blood purification by adsorption of excessive drugs during clinical tr...
supported by a grant from the Suzhou Youth Science and Technology Program(No.KJXW2021067).
Background:As the efficacy of programmed cell death-1/programmed death-ligand 1(PD-1/PD-L1)inhibitors combined with chemotherapy in curing breast cancer is still controversial,this meta-analysis compares the efficacy ...
This work was supported by grants from the National Natural Science Foundation of China(No.22075127,81773291,21872158);Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110105005);atural Science Foundation of Guangdong Province(2021A1515011638).
Beyond traditional endothelium-dependent vessel(EDV),vascular mimicry(VM)is another critical tumor angiogenesis that further forms in many malignant metastatic tumors.However,the existing anti-angiogenesis combined ch...
Lizanell and Colbert Coldwell Foundation;The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding this work,through their research group(No.RG-1435–017)。
Cardiac toxicity is one of the most common side effects of anticancer drugs.Cardiac toxicity results dysfunction of heart including hypotension,heart failure,and even cause death in extreme cases.The potential risk of...
The authors apologize that in Fig.3D,there are duplicate pictures of the active caspase-3 staining between TMZ-treated group and CIS-treated group.The corrected version of Fig.3D has been provided below.The authors de...