CHEMOTHERAPEUTICS

作品数:25被引量:83H指数:5
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相关领域:医药卫生更多>>
相关作者:傅健文陈宏更多>>
相关机构:天津市长征医院天津医科大学总医院更多>>
相关期刊:《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Research》《Journal of Hainan Medical University》更多>>
相关基金:国家自然科学基金国家重点基础研究发展计划上海市教育委员会重点学科基金国家教育部博士点基金更多>>
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A GSH-Responsive Immune-Stimulating Polypeptide Hydrogel Loaded with Chemotherapeutics,IDO Inhibitor and Immune Checkpoint Blocking Antibody for Enhanced Anti-Tumor Chemo-Immunotherapy
《Chinese Journal of Chemistry》2024年第23期2957-2969,共13页Junfeng Ding Tianran Wang Yan Rong Chaoliang He Xuesi Chen 
financially supported by the National Natural Science Foundation of China(Projects 52173147,52203202,51973218);the Scientific and Technological Development Projects of Jilin Province(20240202002GX).
Due to the immunosuppressive tumor microenvironment(TME),T cells are usually inactivated and tend to differentiate into regulatory T cells(Tregs)in the tumor tissues,which seriously hinders the anti-tumor efficiency o...
关键词:Immune-stimulating hydrogel POLYPEPTIDE Stimuli-responsive Immunotherapy Immunosuppressive microenvironment Cancertreatment Drug delivery 
A Dynamic Covalent Bonding-based Nanoplatform for Intracellular Co-Delivery of Protein Drugs and Chemotherapeutics with Enhanced Anti-Cancer Effect被引量:1
《Chinese Journal of Polymer Science》2024年第5期559-569,I0005,共12页Sai-Nan Liu Jia-Hui Meng Li-Yun Cui Hua Chen Lin-Qi Shi Ru-Jiang Ma 
This work was financially supported by the National Key R&D Program of China(Nos.2022YFA1205703 and 2022YFA1205702);the National Natural Science Foundation of China(Nos.51773099,51933006 and 52103183);Haihe Laboratory of Sustainable Chemical Transformations(No.YYJC202102).
Efficient intracellular delivery of protein drugs is critical for protein therapy.The combination of protein drugs with chemotherapeutics represents a promising strategy in enhancing anti-cancer effect.However,co-deli...
关键词:Drug co-delivery Combination therapy Dynamic covalent bond 
Britanin–a beacon of hope against gastrointestinal tumors?
《World Journal of Clinical Oncology》2024年第4期523-530,共8页Agnieszka Kajdanek Damian Kołat Lin-Yong Zhao Mateusz Kciuk Zbigniew Pasieka Żaneta Kałuzińska-Kołat 
Britanin is a bioactive sesquiterpene lactone known for its potent anti-inflammatory and anti-oxidant properties.It also exhibits significant anti-tumor activity,suppressing tumor growth in vitro and in vivo.The curre...
关键词:Britanin Sesquiterpene lactones CHEMOTHERAPEUTICS Gastrointestinal tumors In vitro In vivo 
Monomorphic epitheliotropic intestinal T-cell lymphoma with bone marrow involved: A case report
《World Journal of Clinical Cases》2024年第4期814-819,共6页Fen-Juan Zhang Wen-Juan Fang Cang-Jian Zhang 
Supported by Zhejiang Province Traditional Chinese Medicine Science and Technology Project,No.2024ZL1296.
BACKGROUND Monomorphic epithelial intestinal T-cell lymphoma(MEITL)is a rare type of peripheral T-cell lymphoma.The clinical manifestations are diarrhea,abdominal pain,perforation and an abdominal mass.CASE SUMMARY We...
关键词:Monomorphic epithelial intestinal T-cell lymphoma Autologous stem cell transplantation CHEMOTHERAPEUTICS Case report 
Adult rhabdomyosarcoma combined with acute myeloid leukemia: A case report
《World Journal of Clinical Cases》2024年第3期582-586,共5页Lu Zheng Fen-Juan Zhang 
BACKGROUND Rhabdomyosarcoma is a tumor of mesenchymal origin.Secondary leukemia is a complication of previous transformation to other hematologic disorders or is a treatment-related acute myeloid leukemia secondary to...
关键词:RHABDOMYOSARCOMA Secondary acute myeloid leukocytes CHEMOTHERAPEUTICS Secondary leukemia Case report 
DNA-Polyelectrolyte Composite Responsive Microparticles for Versatile Chemotherapeutics Cleaning被引量:1
《Research》2023年第4期349-359,共11页Chong Wang Jiali Wang Zhuohao Zhang Qiao Wang Luoran Shang 
This work was supported by the National Key Research and Development Program of China(2020YFA0908200);the National Natural Science Foundation of China(22002018);the Innovative Research Team of High-level Local University in Shanghai,and the Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learning.
Drug therapy is among the most widely used methods in disease treatment.However,there remains a trade-off problem between drug dosage and toxicity.Blood purification by adsorption of excessive drugs during clinical tr...
关键词:DOSAGE drugs chemotherapy 
Assessment of the safety and efficacy of combination chemotherapy and PD-1/PD-L1 inhibitor treatment of breast cancer:A meta-analysis
《Chinese Medical Journal》2023年第14期1663-1670,共8页Da Qian Yuhao Xu Yihao Wu Jie Qiu Weimin Hong Xuli Meng 
supported by a grant from the Suzhou Youth Science and Technology Program(No.KJXW2021067).
Background:As the efficacy of programmed cell death-1/programmed death-ligand 1(PD-1/PD-L1)inhibitors combined with chemotherapy in curing breast cancer is still controversial,this meta-analysis compares the efficacy ...
关键词:PD-1/PD-L1 inhibitors Breast cancer CHEMOTHERAPEUTICS META-ANALYSIS 
Self-anti-angiogenesis nanoparticles enhance anti-metastatic-tumor efficacy of chemotherapeutics被引量:1
《Bioactive Materials》2022年第7期179-190,共12页Jiamao Luo Xinxian Zhong Yingming Peng Chenyuan Hao Xiaomei Liang Yulu Yang Xiubo Shi Xuncai Chen Xiao Yi iaoxuan Li Jianhua Wu Jinheng Li Qian Xiao Chentian Wu b Ruojing Lu b Yao Pan Xuejiao Wang Jun-Bing Fan Yifeng Wang Ying Wang 
This work was supported by grants from the National Natural Science Foundation of China(No.22075127,81773291,21872158);Frontier Research Program of Guangzhou Regenerative Medicine and Health Guangdong Laboratory(2018GZR110105005);atural Science Foundation of Guangdong Province(2021A1515011638).
Beyond traditional endothelium-dependent vessel(EDV),vascular mimicry(VM)is another critical tumor angiogenesis that further forms in many malignant metastatic tumors.However,the existing anti-angiogenesis combined ch...
关键词:self-anti-angiogenesis NANOPARTICLES Metastatic ovarian cancer VM EDV 
Methods of screening,monitoring and management of cardiac toxicity induced by chemotherapeutics
《Chinese Chemical Letters》2022年第6期2773-2782,共10页Humayra Afrin Christiancel Joseph Salazar Mohsin Kazi Syed Rizwan Ahamad Majed Alharbi Md Nurunnabi 
Lizanell and Colbert Coldwell Foundation;The authors extend their appreciation to the Deanship of Scientific Research at King Saud University for funding this work,through their research group(No.RG-1435–017)。
Cardiac toxicity is one of the most common side effects of anticancer drugs.Cardiac toxicity results dysfunction of heart including hypotension,heart failure,and even cause death in extreme cases.The potential risk of...
关键词:CARDIOTOXICITY Anticancer drug CHEMOTHERAPY SCREENING BIOMARKER 
Author Correction: Synergistic suppression of noscapine and conventional chemotherapeutics on human glioblastoma cell growth
《Acta Pharmacologica Sinica》2022年第4期1100-1100,共1页Qi Qi Xia Liu Shiyong Li Harish C.Joshi Keqiang Ye 
The authors apologize that in Fig.3D,there are duplicate pictures of the active caspase-3 staining between TMZ-treated group and CIS-treated group.The corrected version of Fig.3D has been provided below.The authors de...
关键词:CORRECTION CIS picture 
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