Low-grade myofibrosarcoma of the maxillary sinus:Two case reports  

作　　者：Anna Mydlak ŁukaszŚcibik Monika Durzynska Jakub Zwoliński Karolina Buchajska Olga Lenartowicz Jakub Kucharz 

机构地区：[1]Department of Head and Neck Cancer,Maria Sklodowska-Curie National Research Institute of Oncology,Warsaw 02-781,Poland [2]Department of Otolaryngology and Head and Neck Oncological Surgery,The 5th Military Clinical Hospital with Polyclinic,Krakow 30-901,Poland [3]Department of Pathology,Maria Sklodowska-Curie National Research Institute of Oncology,Warsaw 02-781,Poland [4]Department of Genitourinary Oncology,Maria Sklodowska-Curie National Research Institute of Oncology,Warsaw 02-781,Poland

出　　处：《World Journal of Clinical Oncology》2024年第4期566-575,共10页世界临床肿瘤学杂志（英文版）

摘　　要：BACKGROUND Low-grade myofibroblastic sarcoma(LGMS)is an extremely rare tumor characterized by the malignant proliferation of myofibroblasts.LGMS most commonly develops in adults,predominantly in males,in the head and neck region,oral cavity,especially on the tongue,mandible,and larynx.This article presents 2 cases of LGMS localized to the maxillary sinus and provides an overview of the available literature.CASE SUMMARY Two patients with LGMS located in the maxillary sinus underwent surgery at the Department of Head and Neck Surgery.Case 1:A 46-year-old patient was admitted to the clinic with suspected LGMS recurrence in the right maxillary sinus(rT4aN0M0),with symptoms of pain in the suborbital area,watering of the right eye,thick discharge from the right nostril,and augmented facial asymmetry.After open biopsy-confirmed LGMS,the patient underwent expanded maxillectomy of the right side with immediate palate reconstruction using a microvascular skin flap harvested surgically from the middle arm.The patient qualified for adjuvant radiotherapy for the postoperative bed,with an additional margin.Currently,the patient is under 1.5 years of observation with no evidence of disease.Case 2:A 45-year-old man was admitted to our clinic with facial asymmetry,strabismus,exophthalmos,and visual impairment in the right eye.Six months earlier,the patient had undergone partial jaw resection at another hospital for fibromatosis.A contrast-enhanced computed tomography scan revealed a tumor mass in the postoperative log after an earlier procedure.An open biopsy confirmed lowgrade fibrosarcoma(rT4aN0M0).The patient qualified for an extended total right maxillectomy with orbital excision and right hemimandibulectomy with immediate microvascular reconstruction using an anterolateral thigh flap.The patient subsequently underwent adjuvant radiotherapy to the postoperative area.After 9 months,recurrence occurred in the right mandibular arch below the irradiated area.The lesion infiltrated the base of the skull,which warranted the withdra

关 键 词：Head and neck cancer Paranasal sinuses Maxillary sinus SARCOMA Low-grade myofibroblastic sarcoma Case report 

分 类 号：R736.4[医药卫生—肿瘤]